关于心力衰竭标志物研究的进展

About research progress of biomarkers in heart failure

心力衰竭的过程中伴随着一系列生物学标记物的变化,涉及心肌牵张标志物、心肌纤维化和重构标志物、心肌损伤标志物、炎症因子、神经内分泌等,某些生物标记物,如脑钠肽(BNP)和氨基末端脑钠肽前体(NT-proBNP)在诊断心衰发挥重要作用,但其具有一定的局限性,因此探究其他生物标记物对于心衰的早期识别、危险评估和判断预后有重要意义。

There are a series of changes of biomarkers during heart failure (HF), which may involve myocardial stretch markers, myocardial fibrosis and remodeling markers, myocardial injury markers, inflammatory factors and neuroendocrine etc. Some biomarkers, such as brain natriuretic peptide (BNP) and N terminal pro brain natriuretic peptide (NT-proBNP), play important roles in diagnosing HF, but they have certain limitations. Therefore, exploration of other biomarkers is of important significance for early identification, risk assessment and prognosis judgment of HF.