血清白细胞介素18、胱抑素C与2型糖尿病下肢血管病变的关系

Relationships between the levels of interleukin-18 and cystatin C,and arterial intima-media thickness of lower extremity in type 2 diabetic patients

目的:探讨血清白细胞介素18(IL-18)和胱抑素C(CysC)与2型糖尿病(T2DM)及下肢血管病变的关系及临床价值。方法:选择112例住院的T2DM病人为A组,同期健康体检者30名为对照组(B组)。彩超测定下肢血管内膜厚度(IMT),A组分为3个亚组:A1亚组(IMT<1.0 mm),A2亚组(1.0 mm≤IMT<1.3 mm),A3亚组(IMT≥1.3 mm)。检测各组空腹血糖(FBG)、糖化血红蛋白(HbA1c)、血脂、肌酐(Cr)、IL-18、CysC等相关指标。结果:A组血清IL-18、CysC水平均高于B组(P<0.01);各亚组的血清IL-18、CysC比较,A3亚组高于A1、A2亚组,A2亚组高于A1亚组(P<0.05);多因素多元线性回归结果显示,IL-18、CysC、TC、FPG与下肢IMT呈正相关。结论:血清IL-18、CysC是IMT的主要影响因素,血清IL-18、CysC与T2DM及下肢IMT存在相关性。

Objective: To investigate the relationhsips between the levels of interleukin 18(IL-18) and cystatin C(CysC),and lower extremity vascular lesions in type 2 diabetes mellitus(T2DM) patients,and its clinical significance. Methods: One hundred and twelve patients with T2DM and 30 healthy people were divided into the group A and group B,respectively.According to the arterial intima-media thickness(IMT) of lower extremity vascular detected by ultrasound,the group A was divided into the subgroup A1(IMT< 1.0 mm ),subgroup A2(1.0 mm≤IMT<1.3 mm) and subgroup A3(IMT≥1.3 mm).The levels of fasting blood glucose(FBG),glycosylated hemoglobin,blood lipid,creatinine,IL-18 and CysC were measured in all groups. Results: The levels of serum IL-18 and CysC in group A were higher than those in group B( P <0.01).The serum levels of IL-18 and CysC in A3 and A2 subgroups were higher than those in A1 and A2 subgroups,and subgroup A1,respectively( P <0.05).Multivariate linear regression analysis showed that the levels of IL-18,CysC,total cholesterol and FBG were positively correlated with the IMT of lower extremity vascular. Conclusions: The serum levels of IL-18 and CysC are the main influencing factors of IMT,and correlated with the T2DM and IMT of lower limb artery.