脑外伤病人血清巨噬细胞炎性蛋白1α含量及其与病情严重程度的相关关系

Study on the relationship between the serum level of macrophage inflammatory protein-1α and disease severity in patients with traumatic brain injury

目的:检测脑外伤病人血清巨噬细胞炎性蛋白1α(MIP-1α)含量检测并探讨其与病情严重程度的相关关系。方法:选择脑外伤病人98例作为观察组,并根据观察组MIP-1α含量中位数进一步分为高MIP-1α组、低MIP-1α组各49例,另取同期在本院进行体检的健康人50名作为对照组。同时采用格拉斯哥昏迷评分法(GCS)评估观察组病人的昏迷程度,测定其血清神经损伤指标、兴奋性氨基酸含量。结果:入院时,观察组血清中MIP-1α含量为(92.16±9.85)pg/mL,显著高于对照组的(74.51±8.68)pg/mL(P<0.01)。高MIP-1α组GCS评分为(7.27±0.91)分,显著低于低MIP-1α组的(11.09±1.82)分(P<0.01)。入院时,高MIP-1α组血清中神经损伤指标胶质纤维酸性蛋白、神经元特异性烯醇化酶、S100B蛋白含量及兴奋性氨基酸谷氨酸、天冬氨酸含量均显著高于低MIP-1α组(P<0.01)。结论:脑外伤病人血清MIP-1α含量上升,且具体含量与脑损伤严重程度呈正相关。

Objective: To investigate the relationship between the serum level of macrophage inflammatory protein-1α(MIP)-1α and disease severity in patients with traumatic brain injury. Methods: Ninety-eight patients with traumatic brain injury were set as the observation group,and subdivided into the high MIP-1α group and low MIP-1α group according to the median of MIP-1α(49 cases each group).Fifty healthy people were set as the control group.At the same time,the coma degree in observation group was assessed using Glasgow Coma Scale(GCS),and the serum nerve injury indices and content of excitatory amino acid were determined. Results: On admission,the serum content of MIP-1α in observation group[(92.16±9.85)pg/mL] was significantly higher than that in control group[(74.51±8.68)pg/mL]( P <0.01).The GCS score in high MIP-1α group(7.27±0.91) was significantly lower than that in low MIP-1α group(11.09±1.82)( P <0.01).On admission,the serum neural damage indices,such as glial fibrillary acidic protein,neuron-specific enolase and S100B,and the serum contents of excitatory amino acid glutamic acid and aspartic acid in high MIP-1α group were significantly higher than those in low MIP-1α group( P < 0.01 ). Conclusions: The serum content of MIP-1α in patients with traumatic brain injury increases,and the specific content is positively correlated with the severity of brain injury.