某医院健康体检人群血清肝脏转氨酶与代谢综合征的关联分析

Analysis of the correlation of serum liver transaminase with metabolic syndrome of health examinees in a hospital

目的:探讨血清肝脏转氨酶的水平与代谢综合征患病风险的关系。方法:收集某医院体检中心健康体检者数据,包括体格检查和实验室检查。共纳入有2 460名研究对象,其中男1 457人,女1 003人,平均年龄(46.64±14.81)岁。根据四分位数法将AST、ALT、AST/ALT比值分为4组(Q1、Q2、Q3、Q4)。采用Spearman相关分析和logistic回归模型分析血清肝脏转氨酶与代谢综合征及其组分的相关性。使用SPSS 21.0软件对数据进行分析处理。结果:调查人群中代谢综合征粗患病率为17.03%。男性患病率高于女性(χ~2=48.542,P<0.05)。AST、ALT水平与代谢组分异常数目呈正相关,而AST/ALT比值与代谢组分异常数目呈负相关。通过调整年龄、吸烟、饮酒变量,男性ALT在Q4水平患代谢综合征风险为Q1的4.96倍(95%CI:3.33～7.38),女性为2.64倍(95%CI:1.29～5.43);男性AST在Q4水平患代谢综合征风险为Q1的2.22倍(95%CI:1.55～3.18)。结论:血清肝脏转氨酶与代谢综合征各组分密切相关。AST、ALT水平的增高会增加代谢综合征的患病风险。

Objective: To understand the relationship between the serum level of liver transaminase and risk of metabolic syndrome. Methods: The data of physical examination and laboratory examination from 2 460 health examinees[including 1 457 males and 1 003 females,an average age for(46.64±14.81) years] in a hospital were investigated.The levels of AST,ALT and ratio of AST to ALT were divided into four groups(Q1,Q2,Q3 and Q4) by quartile method.The relationship between the serum level of liver transaminase and metabolic syndrome was analyzed using the Spearman correlation analysis and logistic regression model,and the data were processed using SPSS 21.0 software. Results: The crude prevalence of metabolic syndrome was 17.03%,which in male was higher than that in female(χ^2=48.542, P <0.05).The levels of AST and ALT were positively correlated with the abnormal number of metabolic components,but the ratio of AST to ALT was negatively correlated with the abnormal number of metabolic components.By adjusting the variates of age,smoking and alcohol,compared with Q1 group,the metabolic syndrome risk of ALT level in Q4 group were 4.96 times in males(95% CI :3.33 to 7.38),and 2.64 times in females(95% CI :1.29 to 5.43),and the metabolic syndrome risk of AST level in Q4 group was 2.22 times in males(95% CI :1.55 to 3.18). Conclusions: Serum liver transaminase is closely related to the components of metabolic syndrome.The increasing levels of AST and ALT may enhance the risk of metabolic syndrome.