亚甲基四氢叶酸还原酶基因多态性与妊娠期高血压疾病的关系研究

Research on relationship between methylenetetrahydrofolate reductase gene polymorphism and gestational hypertension

目的研究亚甲基四氢叶酸还原酶基因多态性与妊娠期高血压疾病的关系。方法选择我院2016年7月～2017年7月收治的无妊娠期高血压患者64例为对照组,选择同期有妊娠期高血压的患者54例为研究组。比较两组患者MTHFR C677T基因检测结果。结果两组患者在MTHFR基因频率TT型、等位基因频率C~*、T~#有统计学意义(P <0.05),两组患者在MTHFR基因频率的AA型、AC型、CC型、等位基因频率A、C上差异无统计学意义(P> 0.05)。结论 MTHFR基因C677T能够作为临床诱发妊娠期高血压的危险因素,在临床上可作为评价患者治疗的指标之一,值得临床进一步研究。

Objective To study the relationship between methylenetetrahydrofolate reductase gene polymorphism and gestational hypertension. Methods 64 patients without gestational hypertension who were admitted and treated in our hospital from July 2016 to July 2017 were selected as the control group and 54 patients with gestational hypertension in the same period were selected as the research objects. The MTHFR C677T gene detection results were compared. Results There no statistically significant difference in MTHFR gene frequency TT type, allele frequency C^* and T^# between two groups(P > 0.05). However, the CC and CT types of the MTHFR gene frequency in the study group were significantly higher than those in the control group. The difference was statistically significant(P < 0.05).There no statistically significant difference in AA type, AC type and CC type of MTHFR gene frequency and allele frequency A and C between two groups(P > 0.05). Conclusion The MTHFR C677T can be as one risk factor for inducing gestational hypertension clinically, which can be used as one of the indexes to evaluate the treatment of patients and is worthy of further clinical study.