萝卜硫素的生物学效应及其在女性生殖系统中的研究进展

Biological Effects of Sulforaphane and It′s Role in Female Reproductive System

萝卜硫素(1-异硫氰酸-4-甲磺酰基丁烷,sulforaphane,SFN),又名莱菔子素,是一种提取自西兰花属植物的生物活性物质,是迄今发现的抗氧化能力较强的物质之一。当机体发生氧化应激刺激时,萝卜硫素可以通过活化核因子E2相关因子2(Nrf2)/抗氧化反应元件(ARE)通路,诱导多种抗氧化蛋白和解毒酶的表达,从而起到抗氧化效应。萝卜硫素还可与其他细胞靶点直接反应,从而发挥相应生物学效应,如诱导细胞凋亡、调节炎性介质等。因此,萝卜硫素已在多种疾病中被研究及使用,包括消化系统、呼吸系统、心血管系统和肿瘤等。女性生殖系统的抗氧化研究是目前的热点之一,而萝卜硫素在该系统的研究较少。现就萝卜硫素的基本结构、生物学效应以及其在女性生殖系统中的研究进展进行综述。

Sulforaphane (1-isothiocyanate-4-methanesulfonylbutane, SFN), also known as raphanin, is a bioactive substance extracted from broccoli plants, and is one of the strong antioxidant found so far. Once oxidative stress stimulus occurs, sulforaphane can induce the expression of various antioxidants and detoxifying enzymes by activating the Nrf2/ARE pathway to exert an antioxidant effect. The sulforaphane can also directly react with other cellular targets to exert biological effects such as inducing apoptosis and regulating inflammatory mediators. Sulforaphane has been used as an antioxidant in various disease research, such as digestive disease, respiratory diseases, cardiovascular diseases and tumors. However, there are few studies on its function in the female reproductive system. This article reviews the basic structure, biological effects and research progress of sulforaphane in female reproductive system.