多环萜类化合物自组装研究及应用

Study and application in self-assembled behavior of polycyclic terpenoids

多环萜类化合物因含有独特的刚性环骨架、手性结构和多修饰位点,具有优异的自组装功能。由于萜数量和环结构不同,萜类化合物具有多种自组装形态和功能,在材料领域具有广泛的应用而备受关注。结合化合物结构特点和组装原理(电荷作用、亲水疏水作用、π-π堆积、氢键、空间位阻等作用),综述了多环萜类化合物的自组装研究现状及在靶向载药、功能材料和离子识别等领域的应用。并对多环萜类化合物自组装研究进行展望,指出开展萜类衍生物自组装构效关系研究以及理论计算辅助实验进行自组装机理研究的重要意义。

Due to the unique rigid ring skeleton,chiral structure and multiple modification sites,polycyclic terpenoids show excellent self-assembly properties.Various numbers of terpene functional groups and different ring structure impart terpenoids with serval self-assembled morphologies and functions.It has received increasing attention due to its wide range of applications in the field of materials.On the basis of the structural characteristics and self-assembled principle of the compound(interaction between charges,hydrophilic interaction/hydrophobic interaction,pi-pi stacking,hydrogen bonding,steric effects,ect),the self-assembled study progress of polycyclic terpenoids and their application in targeted drug delivery,functional materials,and ion identification were summarized.Furthermore,the research trends of self-assembly of polycyclic terpenoids were proposed.The research on the structure-activity relationship of terpenoid derivatives self-assembling and self-assembly mechanism based on theoretical calculation experiments were very important for self-assembly study of terpeniod.