精神分裂症幻听患者静息态脑功能低频振幅研究

A resting functional MRI study on schizophrenic patients with auditory hallucination

目的运用静息态功能磁共振成像(fM RI)中的低频振幅(ALFF)参量评价精神分裂症幻听相关的神经元自发活动改变。方法纳入精神分裂症幻听组患者16例,非幻听组患者17例。采集所有研究对象的静息态fM RI数据并通过后处理计算得到ALFF值,比较精神分裂症幻听组和非幻听组ALFF组间存在差异的脑区;采用阳性与阴性症状量表(PANSS)对精神分裂症症状进行评估,分析差异脑区ALFF值和幻听症状的相关性。结果与非幻听组比较,幻听组ALFF显著降低的脑区主要位于枕叶皮层,ALFF显著升高的脑区有左侧角回、缘上回、颞上回。左侧角回的ALFF值与幻听症状评分呈正相关关系(P=0.006,R=0.550),枕叶皮层的ALFF值与幻听症状评分呈负相关关系(P=0.007,R=-0.53)。结论精神分裂症幻听患者的静息态自发脑功能活动异常可能与听觉语言处理皮层过度激活及视觉信息处理功能受损有关。

Objective To explore local changes of spontaneous brain activity related to auditory hallucination in schizophrenia using amplitude of low frequency fluctuation (ALFF). Methods 33 schizophrenia patients with (16) and without (17) auditory hallucination underwent resting functional MRI study. Values of ALFF were calculated and compared between the patients with and without auditory hallucination. Correlation analysis between ALFF values and the severity of auditory hallucination was performed. Results The ALFF values were significantly lower in the occipital cortex and significantly higher in the left angular gyrus, supramarginal gyrus and superior temporal gyrus of patients with than that of patients without auditory hallucination. The correlation analysis showed that the ALFF value of left angular gyrus was positively correlated (P=0.006, R=0.550) and the ALFF value of the occipital cortex was negatively correlated (P=0.007,R=-0.53) with severity of auditory hallucination. Conclusion The functional abnormalities of local spontaneous brain activity in the schizophrenia patients with auditory hallucination suggest that the auditory language processing function is over-activated and the visual information processing function is impaired.