小胶质细胞与抑郁症发病机制研究进展

Advances in research on the pathogenesis of microglia and depression

经过几十年的深入研究,抑郁症发病机制尚不明确,致使治疗效果不佳,反复发作,给患者家庭和社会带来巨大的负担。多年来,在对抑郁症治疗过程的不断探索中,大多数学者聚焦于中枢神经系统神经元对抑郁症的作用,而忽视了其他细胞对抑郁症的影响。随着研究的深入,中枢神经系统中的许多免疫活性细胞,尤其是小胶质细胞在抑郁症发生与发展中的作用逐步被人们发现。小胶质细胞可通过影响中枢神经系统稳态导致抑郁发生,本文以小胶质细胞与抑郁症为切入点作一综述。

Despite decades of in-depth research,the pathogenesis of depression is still unclear and drug treatment is not effective.Depression often occurs repeatedly and bring sheavy financial burden tofamilies and society.Over the years,during the exploration of depression treatment,most studies have focused on the role of neurons in central nervous system with less attention to other cells.With further research,the role of immunocompetent cells,especially microglia,has gradually been discovered in the occurrence and development of depression.Microglia can cause depression by affecting the central nervous system homeostasis.This article reviews the microglia and depression as the starting point.