雌激素受体(GPR30)单核苷酸多态性与子宫颈癌的相关性

Correlation between estrogen receptor (GPR30) single nucleotide polymorphisms and cervical carcinoma

目的:探讨雌激素受体(GPR30)单核苷酸多态性与子宫颈癌的相关性及其诊断价值。方法:选取2016年5月至2017年5月来我院就诊并进行治疗的子宫颈癌患者100例为研究组,选取同期患有子宫肌瘤或子宫息肉的患者100例作为对照组,随后测定两组雌激素受体GPR30、雌激素受体、孕激素受体表达含量以及GPR30的位点基因,并分析雌激素受体(GPR30)单核苷酸多态性与子宫颈癌的相关性。结果:在体重指数(BMI)、年龄方面,对照组与研究组无较大差异(P>0.05),而在怀孕次数、初次性生活年龄、文化程度、HPV感染率方面,两组间差异较大(P<0.05);两组患者行GPR30、ER、PR检查后,三者在研究组中的检出率明显高于对照组,差异具有统计学意义(P <0. 05),且GPR30的检出率皆高于ER、PR,且差异具有统计学意义(P <0. 05);两组患者在GG、GA、AA基因型上差异不大,无统计学意义(P> 0. 05);比较等位基因,在rs3808351位上,研究组的G基因明显高于对照组,而A基因明显低于对照组,差异具有统计学意义(P<0. 05)。结论:GPR30 rs3808351等位点G等位基因的检测在子宫颈癌的诊断以及指导治疗中意义重大,应在临床上加以推广。

Objective:To investigate the correlation between estrogen receptor(GPR30)single nucleotide polymorphism and cervical cancer and its diagnostic value.Methods:From May 2016 to May 2017 year in our hospital,cervical cancer patients(100 cases)were selected as the study group,the patients with Uterine leiomyoma or uterine polyp in 100 cases as control group.Estrogen receptor gene GPR30,estrogen receptor,progesterone receptor expression and GPR30 content were detected,and the relationship between estrogen receptor(GPR30)single nucleotide polymorphism and cervical cancer was analysed.Results:In body mass index(BMI)and age,the control group and the study group had no significant difference(P>0.05),and in the number of pregnancy,age at first sex,culture degree,the infection rate of HPV,there was the larger the difference between the two groups(P<0.05).After GPR30,ER,PR examination,the detection rate in the study group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05),and the detection rate of GPR30 was higher than that of ER,PR,and the difference was statistically significant(P<0.05).In GG,GA,AA genotype,there was no statistical significance between the two groups(P>0.05).G gene in study group was significantly higher than the control group,while the A gene was significantly lower than the control group,and the difference was statistically significant(P<0.05).Conclusion:GPR30(rs3808350)allele G is of great clinical value in the diagnosis and treatment of cervical cancer.