3942例住院抑郁症患者用药分析

Analysis of Drug Use in 3942 Inpatients with Depression

目的:了解抑郁症患者用药情况。方法:通过医院信息系统,调取2014年9月至2017年12月新乡医学院第二附属医院3 942例住院抑郁症患者的病历资料,对抗抑郁药的使用情况进行统计分析。结果:3 942例患者共使用抗抑郁药8 549例次,使用例次数排序居前3位的药品为米氮平(2 047例次,占23.94%)、艾司西酞普兰(1 339例次,占15.66%)和文拉法辛(1 121例次,占13.11%);联合用药共14 001例次,使用例次数排序居前3位的药品为劳拉西泮(1 760例次,占12.57%)、阿普唑仑(1 745例次,占12.46%)和丁螺环酮(1 699例次,占12.13%)。结论:选择性5-羟色胺再摄取抑制剂、去甲肾上腺素能和特异性5-羟色胺能抗抑郁药、5-羟色胺及去甲肾上腺素再摄取抑制剂以及新型的5-羟色胺平衡抗抑郁药成为治疗抑郁症的首选药物,抗抑郁药与苯二氮■类药物联合使用率最高。

OBJECTIVE: To investigate the drug use in patients with depression. METHODS: Through the hospital information system, the medical records of 3 942 inpatients with depression from the Second Affiliated Hospital of Xinxiang Medical University from Sept. 2014 to Dec. 2017 were collected, and the use of antidepressants was statistically analyzed. RESULTS: A total of 8 549 case-times antidepressants were used in 3 942 patients, the top three drugs ranked by number of cases used were mirtazapine(2 047 case-times, 23.94%), escitalopram(1 339 case-times, 15.66%) and venlafaxine(1 121 case-times, 13.11%);in 14 001 case-times of combined drug use, the top three drugs ranked by number of cases used were lorazepam(1 760 case-times, 12.57%), alprazolam(1 745 case-times, 12.46%) and buspirone(1 699 case-times, 12.13%). CONCLUSIONS: SSRIs, NaSSA, SNRIs and SMA become the first choice for treatment of depressive disorders, the rate of drug combination of antidepressants and benzodiazepines took the lead.