2014年4月至2017年3月解放军总医院门诊口服降糖药应用分析

Analysis of Application of Oral Hypoglycemic Drugs in Outpatients of PLA General Hospital from Apr. 2014 to Mar. 2017

目的:了解解放军总医院(以下简称"我院")门诊口服降糖药的使用情况,探讨用药特点及用药趋势,为临床合理用药提供参考。方法:采用限定日剂量分析法,对2014年4月至2017年3月我院门诊口服降糖药的使用数据进行回顾性统计分析。结果:2014年4月至2017年3月我院门诊口服降糖药的销售金额呈增长趋势,销售金额排序居前4位的口服降糖药为α-葡萄糖苷酶抑制剂、双胍类药物、磺酰脲类药物和二肽基肽酶-4抑制剂;复方制剂、二肽基肽酶-4抑制剂的销售金额增长明显;二甲双胍(中美上海施贵宝制药有限公司)、阿卡波糖[拜耳(中国)有限公司北京分公司]和格列美脲[赛诺菲安万特(北京)制药有限公司]的用药频度排序居前3位;口服降糖药的限定日费用为0.60～18.40元,价格范围较广;4种二肽基肽酶-4抑制剂的销售金额排序/用药频度排序≤1;国产药品的销售金额占比<10%。结论:我院门诊口服降糖药的品种多样,与最新指南推荐用药相符;二甲双胍是临床首选药品,但部分药品的销售金额呈阶段性突增状态,需对销售金额排序/用药频度排序≤1的品种加强监管,确保临床合理用药。

OBJECTIVE: To investigate the application of oral hypoglycemic drugs in the outpatient department of PLA General Hospital(hereinafter referred to as "our hospital"), and to explore the characteristics and trends of drug application, so as to provide reference for the clinical rational drug application. METHODS: A retrospective statistical analysis was performed on the data of oral hypoglycemic drugs in our hospital from Apr. 2014 to Mar. 2017 by using the defined daily dose analysis method. RESULTS: From Apr. 2014 to Mar. 2017, the consumption sum of oral hypoglycemic drugs in our hospital showed an increasing trend. The top 4 oral hypoglycemic drugs ranked by consumption sum were respectively α-glucosidase inhibitors, biguanides, sulfonylureas and dipeptidyl peptidase-4 inhibitors. The consumption sum of compound preparation and dipeptidyl peptidase-4 inhibitors increased significantly. The top 3 drugs ranked by medication frequency were respectively metformin(Bristo-Myers Squibb Co., Ltd.), acarbose [Bayer(China) Co., Ltd. Beijing Branch] and glime urea [Sinofi Aventis(Beijing) Pharmaceutical Co., Ltd.]. The defined daily cost of oral hypoglycemic drugs was 0.60-18.40 yuan, with a wide price range. The sequence of consumption sum/medication frequency of 4 kinds of dipeptidylpeptide-4 inhibitors was less than or equal to 1. Domestic drugs accounted for only about 8% of the consumption sum. CONCLUSIONS: The varieties of oral hypoglycemic drugs in the outpatient department of our hospital are various, which are consistent with the latest guidelines. Metformin is the preferred drugs for clinical application, but the consumption sum of some drugs is in a stage of sudden increase, so it is necessary to strengthen the supervision of the varieties with the sequence of consumption/medication frequency less than or equal to 1 to ensure rational clinical application.