细胞外泛素及其受体CXCR4与AMI相关性研究进展

Research Progress of Extracellular Ubiquitin and Its Receptor CXCR4 in Acute-Myocardial Infarction

急性心肌梗死为供养心肌的冠状动脉在粥样硬化斑块基础上发生急性、持久性缺血缺氧所致的心肌坏死,是全球死亡率最高的疾病之一。提高梗死区心肌细胞的存活、逆转进行性心室重构是提高预后的关键。泛素是细胞内参与蛋白质降解的小分子多肽,而体液中的细胞外泛素可通过受体CXCR4发挥多种功能。近来相关研究显示细胞外泛素及其受体CXCR4对心肌组织的细胞形态和功能均有影响,对急性心肌梗死(AMI)后心肌组织具有保护作用,笔者将对此作一综述,以期为解决AMI难题提供新的思路和靶点。

Acute myocardial infarction is one of the most deadly diseases in the world.Promoting cardiomyocytes survival in the infarctedarea and reversing the myocardial remodeling are the keys to improve the prognosis of AMI.Ubiquitin is a small polypeptide involved in protein degradation in cells,whereas extracellular ubiquitin in body fluid can function through its receptor CXCR4.Recent studies have shown that extracellular ubiquitin and CXCR4have effects on the morphology and function of cardiomyocytes and can efficiently improve the heart function and survival after myocardial infarction.This review summarizes the role of extracellular ubiquitin in myocardial remodeling and may provide a new and potentially useful therapy for solving the problem of acute myocardial infarction(AMI).