老年桥本氏甲状腺炎患者碘营养与SOD、IP-10及甲状腺激素水平相关研究

A study of the correlation of iodine nutrition with SOD,IP-10,and thyroid hormone in elderly patients with Hashimoto's thyroiditis

目的:探讨老年桥本氏甲状腺炎(Hashimoto thyroiditis,HT)患者碘营养状况与超氧化物歧化酶(superoxide dismutase,SOD)活力、干扰素诱导蛋白-10(interferon-inducible protein 10,IP-10)和甲状腺激素水平的相关性。方法:通过检测92例唐山市工人医院内分泌科就诊的老年桥本氏甲状腺炎患者,及同期体检的40例临床健康老年人的尿碘、血清SOD活力、IP-10水平及甲状腺功能等相关指标,比较不同碘营养状况对SOD活力、IP-10水平、HT发病和甲状腺激素水平的影响,分析碘、SOD和IP-10三者之间的相关性。结果:与对照组相比,老年桥本患者尿碘(216.63μg/L)和IP-10水(194.41 ng/L)平均较高,而SOD(92.99 U/m L)活性较低。碘充足组促甲状腺激素、血清游离三碘甲状腺原氨酸、血清游离甲状腺素和IP-10水平明显升高,SOD活力明显降低。相关分析发现尿碘与SOD活性呈负相关,与血清IP-10水平成正相关,血清SOD活性与IP-10水平呈负相关(r=0.662)。结论:过量碘摄入与老年桥本氏甲状腺炎相关,高碘能够影响患者甲状腺功能、氧化应激状态和趋化因子水平。

Objective:To investigate the correlation of iodine nutritional status with superoxide dismutase(SOD)activity and levels of interferon-inducible protein 10(IP^^-10)and thyroid hormone in elderly patients with Hashimoto’s thyroiditis(HT). Methods:A total of 92 elderly patients with HT who visited the Department of Endocrinology in Tangshan Workers’ Hospital and 40 clinically healthy elderly subjects who had physical examinations during the same period were tested for their serum SOD activity,levels of urine iodine and IP^-10,and other indices related to thyroid function. SOD activity,the levels of IP^-10 and thyroid hormones,and the incidence of HT were compared between the subjects with different nutritional status. The correlation between iodine,SOD,and IP^-10 was analyzed.Results:Compared with the control group,the elderly patients with HT had higher mean levels of urinary iodine(216.63 μg/L)and IP^-10(194.41 ng/L),but lower SOD activity(92.99 U/m L). The group with adequate iodine had significantly increased levels of thyroid stimulating hormone,free triiodothyronine,free thyroxine,and IP^-10,but significantly decreased SOD activity. A correlation analysis showed that urinary iodine was negatively correlated with SOD activity and positively correlated with serum IP^-10 level,and serum SOD activity was negatively correlated with the IP^-10 level(r=0.662). Conclusion:Excessive iodine intake is associated with HT in the elderly. High iodine level can affect the thyroid function,oxidative stress,and chemotactic factor level of patients.