重庆市2805例健康女性DXA法骨密度现况分析

An analysis of DXA-measured bone mineral density in 2805 healthy women in Chongqing,China

目的:通过测量重庆市2 805人次健康女性骨密度,初步建立重庆地区各年龄段骨密度数据库及骨峰值,并探讨年龄、体质量指数对骨密度变化的影响。方法:选取2011年6月至2015年11月在重庆市妇幼保健院体检的健康女性,采用双能X线骨密度仪测量腰椎1~4和股骨颈骨密度。结果:2 805例健康女性骨质疏松症发生率为11.44%;随着年龄增长,骨质疏松症比例增加(趋势卡方检验:χ2=403.800,P=0.000);50岁以上骨质疏松症发生率为26.04%,50岁前后的正常骨量和骨质疏松症比例均有统计学差异(P=0.000);35~39岁达到腰椎1~4骨密度峰值(1.116±0.120)g/cm2,17~19岁达到股骨颈骨密度峰值(0.935±0.146)g/cm2。结论:本研究建立了重庆市经DXA法测量腰椎及股骨颈骨密度的大数据。

Objective:To establish a preliminary bone mineral density(BMD)database and the peak BMD of people from different age groups in Chongqing,China,through the measurement of BMD in 2 805 healthy women in Chongqing,and to investigate the effect of age and body mass index on BMD. Methods:Dual-energy X-ray absorptiometry(DXA)was used to determine the BMD of the lumbar vertebrae(L1-4)and the femoral neck of healthy women who had physical examinations in Chongqing Health Center for Women and Children from June 2011 to November 2015. Results:The prevalence rate of osteoporosis in 2 805 healthy women was 11.44%,and it increased with age(χ2=403.800,P=0.000). The prevalence rate of osteoporosis in women over 50 years of age was 26.04%;there were significant differences in the proportions of women with normal bone mass and osteoporosis before and after the age of 50 years(P=0.000). The peak BMD(1.116±0.120)g/cm2 of lumbar vertebrae was reached at the age of 35 to 39 years,and the peak BMD(0.935±0.146)g/cm2 of femoral neck was reached at the age of 17 to 19 years. Conclusion:In this study,a DXA-measured BMD database of lumbar vertebrae and femoral neck of people in Chongqing was established.