多索茶碱与噻托溴铵粉联合治疗慢阻肺对肺功能的影响

Effect of Doxofylline combined with Tiotropium Bromide powder on pulmonary function in patients with chronic obstructive pulmonary disease

目的探讨多索茶碱与噻托溴铵粉联合治疗慢阻肺对肺功能的影响。方法选取2016年3月～2017年3月我院收治的72例慢阻肺患者,将其随机分为观察组(36例)和对照组(36例)。对照组接受单纯多索茶碱治疗,观察组接受多索茶碱联合噻托溴铵粉治疗。对两组患者临床疗效进行统计分析。结果与治疗前相比,两组患者治疗后的FEV1/FVC、FVC、FEV1均显著升高(P<0.05);治疗后,观察组患者的FEV1/FVC、FVC、FEV1均高于对照组(P<0.05)。观察组患者治疗的总有效率91.67%(33/36)显著高于对照组61.11%(22/36)(P<0.05)。结论针对慢阻肺患者,采用多索茶碱与噻托溴铵粉联合治疗,能够促进患者康复速度的加快,有效缓解患者的临床症状,有效改善患者的生活质量,极大程度上改善患者肺功能,具有临床应用价值。

Objective To explore the effect of doxofylline combined with tiotropium bromide powder on pulmonary function in patients with chronic obstructive pulmonary disease. Methods Seventy-two patients with chronic obstructive pulmonary disease admitted to our hospital from March 2016 to March 2017 were randomly divided into observation group (36 cases) and control group (36 cases). The control group was given simple doxofylline treatment, and the observation group was given doxofylline combined with tiotropium bromide powder. The clinical efficacy of the two groups was statistically analyzed. Results Compared with those before treatment, the FEV1/FVC, FVC, and FEV1 of the two groups were significantly increased after treatment(P<0.05). After treatment, the FEV1/FVC, FVC, and FEV1 of the observation group were higher than those of the control group(P<0.05). The total effective rate of treatment in the observation group was 91.67%(33/36), which was significantly higher than that in the control group [61.11%(22/36)](P<0.05). Conclusion For patients with COPD, the combination of doxofylline and tiotropium bromide powder can accelerate the recovery of patients, effectively alleviate clinical symptoms, improve the quality of life of patients, and significantly improve lung function. Therefore, it has great clinical application value.