血栓通联合阿托伐他汀治疗对短暂性脑缺血发作患者颈动脉粥样硬化斑块、血脂及血流变的影响分析

Effect of Xueshuantong Combined with Atto Vastatin on Carotid Atherosclerotic Plaque, Blood Lipids and Hemorheology in Patients with Transient Ischemic Attack

目的:探讨血栓通联合阿托伐他汀治疗对短暂性脑缺血发作患者颈动脉粥样硬化斑块、血脂及血流变的影响。方法:以我院2016年8月至2017年8月间收治的52例短暂性脑缺血发作患者为研究对象,患者均接受检查并发现存在颈动脉粥样硬化斑块,将患者随机分做观察组、对照组各26例,两组均行常规药物、阿托伐他汀治疗,观察组增添血栓通治疗,统计两组治疗前后颈动脉斑块大小、内膜中层厚度(IMT)情况;记录两组甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)等血脂情况变化;观察两组血小板计数(PLT)、红细胞压积(PCV)、纤维蛋白原(Fb)等血液流变指标。结果:治疗后,患者斑块大小、IMT指标均显著性降低,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,观察组TG、TC、LDL-C指标均低于对照组,HDL-C水平高于对照组,且两组治疗后相比治疗前,各项指标均明显改善,对比均存在统计学意义(P<0.05);经治疗,两组PLT、PCV、Fb指标均有显著降低,组间对比,观察组降低幅度更高(P<0.05)。结论:应用血栓通及阿托伐他汀作为方案对短暂性脑缺血发作患者进行治疗,可有效改善患者颈动脉粥样硬化病情,有助于稳定血脂及血流变情况,促进患者康复。

Objective: To investigate the effects of thrombotic therapy combined with Atto vastatin on carotid atherosclerotic plaque, blood lipids and hemorheology in patients with transient ischemic attack. Methods: 52 patients with transient ischemic attack admitted to our hospital from August 2016 to August 2017 were all examined and found to have carotid atherosclerotic plaques. The patients were randomly divided into two groups: the control group (n=26), and the control group (n=26). Both groups were treated with routine drugs, Atto vastatin, the observation group added thrombotic therapy, the size of carotid plaque and intima-media thickness (IMT) were counted before and after treatment in the two groups. Triacylglycerol (TG), total cholesterol (TC), low density lipoprotein (LDL-C) high density lipoprotein (HDL-C) and other lipid changes were recorded;Platelet count,(PLT), hematocrit,(PCV), fibrinogen (Fb) and other hemorheological indexes were observed. Results: After treatment, the plaque size and IMT index of the patients decreased significantly, and the observation group was lower than the control group (P<0.05). After treatment, the TG, TC, LDL-C index of the observation group was lower than that of the control group, and the level of HDL-C was higher than that of the control group. All the indexes were improved significantly (P<0.05), the PLT, PCV, Fb indexes of the two groups were significantly lower than those of the control group (P<0.05), and that of the observation group was higher than that of the control group (P<0.05). Conclusion: Xueshuantong and Atto vastatin can effectively improve the condition of carotid atherosclerosis, stabilize blood lipid and hemorheology, and promote the recovery of patients with transient ischemic attack.