摘要
1例48岁男性患者,诊断为急性粒细胞性白血病M2a,粒细胞缺乏伴发热合并肺部感染。给予注射用亚胺培南西司他丁钠(1.0 g,q 8 h,ivgtt)等抗感染治疗后,出现频繁阵发性呃逆。临床药师对患者进行药学监护,探讨可能的药物与不良反应关联性,考虑为注射用亚胺培南西司他丁钠所致,建议停用注射用亚胺培南西司他丁钠,并加用肌松药巴氯芬片(5 mg,tid)治疗呃逆,最终患者好转出院。
A 48-year-old male patient diagnosed as granulocytic leukemia M2a developed agranulocytosis with fever and pulmonary infection. After taking imipenem and cilastatin sodium for injection (1.0 g, q 8 h, ivgtt) for anti-infective treatment, the patient developed frequent paroxysmal hiccups. Clinical pharmacist investigated the correlation between the possible drug and adverse reaction. And then the hiccup caused by imipenem and cilastatin sodium for injection was considered. So imipenem and cilastatin sodium for injection was stopped and the muscle relaxant baclofen tablets were given to the patient according to the advice of clinical pharmacist. Finally, the patient was discharged with a good healthy condition.
作者
李琳
LI Lin(Department of Pharmacy, Ganzhou Municipal Hospital, Ganzhou 341000, China)
出处
《中国药物应用与监测》
CAS
2019年第2期122-123,共2页
Chinese Journal of Drug Application and Monitoring
关键词
注射用亚胺培南西司他丁钠
巴氯芬
顽固性呃逆
临床药师
药品不良反应
Imipenem and cilastatin sodium for injection
Baclofen
Intractable hiccup
Clinical pharmacist
Adverse drug reaction
