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左甲状腺素钠治疗妊娠合并甲减的效果及对患者血清TSH水平影响 被引量:5

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摘要 目的:研究分析左甲状腺素钠对妊娠合并甲减的临床干预效果及剂量,并探究血清TSH水平。方法:以2016年9月~2018年1月我院收治并确诊妊娠合并甲减患者84例为研究对象,根据信封法随机分为两组。实验组42例采用低剂量左甲状腺素钠(25μg/次);对照组采用高剂量左甲状腺素钠(75μg/次),对比研究干预效果及血清激素水平。结果:实验组显效21例,有效16例,无效5例,与对照组无明显差异,P>0.05;治疗后实验组血清TSH水平低于对照组,FT3及FT4高于对照组,P<0.05,但均处于正常范围;两组妊娠结局对比差异不明显,P>0.05。结论:对妊娠合并甲减给予左甲状腺素钠剂量能够保证临床治疗效果,改善激素水平,可考虑临床推广。
作者 胡会平
出处 《北方药学》 2019年第5期128-129,共2页 Journal of North Pharmacy
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  • 1Tirosh D, Benshalom -Tirosh N, Novack L, et al. Hypothyroid- ism and diabetes mellitus a risky dual gestational endocrinopa- thy[J]. Peer J, 2013, 1(1): 52.
  • 2单忠艳.妊娠和产后甲状腺疾病诊治指南[c].中华医学会第十-次全国内分泌学学术会议,广州,2012.
  • 3Prats - Puig A, Sitjar C, Ribot R, et al. Relative hypoadipone- ctinemia, insulin resistance, and increased visceral fat in euthyroid prepubertal girls with low - normal serum free thyroxine [ J ]. Obe- sity (Silver Spring), 2012, 20(7): 1455-1461.
  • 4Yang SJ, Kim TN, Baik SH, et al. Insulin secretion and insulin resistance in Korean women with gestational diabetes mellitus and impaired glucose tolerance [ J ]. Korean J Intern Med, 2013, 28 (3) : 306 -313.
  • 5Lazarus JH, Bestwick JP, Channon S, et al. Antenatal thyroid screening and childhood cognitive function [J]. N Engl J Med, 2012,366(6) :493-501. DOI: 10.1056/NEJMoa1106104.
  • 6Bemardi LA, Cohen RN, Stephenson MD. Impact of subclinical hypothyroidism in women with recurrent early pregnancy loss [J] Fertil Steril, 2013, 100 (5) : 1326-1331. DOI: 10.1016/j. fertnstert.2013.07.1975.
  • 7Zhang L, Zhang ZY, Ye HY, et al. Association between the clinical classification of hypothyroidism and reduced TSH in LT4 supplemental replacement treatment for pregnancy in China [J]. Gynecol Endocrinol, 2015: 1-5. DOI: 10.3109/09513590.2015. 1121228.
  • 8Kim HS, Kim BJ, Oh S, et al. Gestational age-specific cut-off values are needed for diagnosis of subclinical hypothyroidism in early pregnancy [J]. J Korean Med Sci, 2015, 30 (9) : 1308- 1312. DOI: 10.3346/jkms.2015.30.9.1308.
  • 9Vissenberg, R. , vandenboogaard, E. , vanweiy, M. et al. Treatment ofthyroid disorders before conception and in early pregnancy : A system-atic review [J]. HUM REPROD UPDATE,2012,18(4) :360-373.
  • 10Goel,P. ,Kaur,J. ,Saha,P. K. et al. Prevalence, associated risk fac-tors and effects of hypothyroidism in pregnancy : A study from northIndia [J]. GYNECOL OBSTET INVES,2012,74(2) :89-94.

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