苏芪定喘胶囊配合胸腺法新及呼吸康复训练对慢阻肺稳定期的干预作用

Intervention effect of Suqi Dingchuan capsule with thymalfasin and respiratory rehabilitation training in stable stage of chronic obstructive pulmonary disease

目的观察苏芪定喘胶囊配合胸腺法新及呼吸康复训练对慢性阻塞性肺疾病(慢阻肺,COPD)稳定期影响。方法 80例慢阻肺稳定期患者,随机分为治疗组和对照组,各40例。两组均给予常规治疗,治疗组在常规治疗基础上加服苏芪定喘胶囊配合胸腺法新及呼吸康复训练。比较两组患者的临床疗效及治疗前后第1秒用力呼气容积占预计值百分比(FEV1%)、第1秒用力呼气容积占用力肺活量的比值(FEV1/FVC)、呼吸困难程度评分和生活质量评分。结果随访期间因患者顺应差等脱落5例,其中治疗组3例,对照组2例。治疗组患者的总有效率为94.59%,显著高于对照组的78.95%,差异具有统计学意义(P<0.05)。治疗后,两组患者的FEV1%和FEV1/FVC水平均优于治疗前,且治疗组优于对照组,差异具有统计学意义(P<0.05)。治疗后,两组患者的呼吸困难程度评分和生活质量评分均优于治疗前,且治疗组优于对照组,差异具有统计学意义(P<0.05)。结论苏芪定喘胶囊配合胸腺法新及呼吸康复训练治疗慢阻肺稳定期能阻止肺通气功能的下降,改善患者生活质量,提升综合疗效。

Objective To observe the effect of Suqi Dingchuan capsule with thymalfasin and respiratory rehabilitation training in stable stage of chronic obstructive pulmonary disease(COPD). Methods A total of 80 patients with stable stage of chronic obstructive pulmonary disease were randomly divided into treatment group and control group, with 40 cases in each group. Comparison were made on clinical efficacy and percentage of forced expiratory volume(FEV1%), forced expiratory volume/forced vital capacity(FEV1/FVC), dyspnea score and quality of life score before and after treatment between the two groups. Results During the follow-up period, 5 patients dropped out due to poor compliance, including 3 cases in the treatment group and 2 cases in the control group. The treatment group had significantly higher total effective rate as 94.59% than 78.95% in the control group, and the difference was statistically significant(P<0.05). After treatment, both groups had better FEV1% and FEV1/FVC than those before treatment, and the treatment group was better than the control group. Their difference was statistically significant(P<0.05). After treatment, both groups had better dyspnea score and quality of life score than those before treatment, and the treatment group was better than the control group. Their difference was statistically significant(P<0.05). Conclusion Suqi Dingchuan capsule with thymalfasin and respiratory rehabilitation training can prevent the decline of pulmonary ventilation function, improve the quality of life of patients with stable stage of chronic obstructive pulmonary disease, and improve the comprehensive efficacy.