探讨缩宫素联合卡贝缩宫素预防阴道分娩产后出血的临床疗效

Investigate the clinical efficacy of oxytocin combined with carbetocin in preventing postpartum hemorrhage in vaginal delivery

目的观察在预防阴道分娩产后出血中采取缩宫素联合卡贝缩宫素的临床疗效。方法 150例阴道分娩产妇,根据随机数字表法分为对照组和联合组,各75例。对照组产妇仅采取缩宫素预防产后出血,联合组产妇采取缩宫素联合卡贝缩宫素预防产后出血。比较两组产妇产后2、24 h出血量、心率差、产后出血情况与不良反应发生情况。结果联合组产妇产后2、24 h出血量与心率差明显优于对照组,差异具有统计学意义(P<0.05)。联合组产妇产后出血率为1.33%,不良反应发生率为1.33%;对照组产妇产后出血率为10.67%,不良反应发生率为9.33%。联合组产妇产后出血率、不良反应发生率低于对照组,差异具有统计学意义(P<0.05)。结论在预防阴道分娩产妇产后出血中,采取缩宫素联合卡贝缩宫素,可有效减少产妇产后出血量,平稳心率,降低产后出血及不良反应发生率,效果理想。

Objective To observe the clinical efficacy of oxytocin combined with carbetocin in preventing postpartum hemorrhage in vaginal delivery. Methods A total of 150 vaginal delivery maternal women were divided by random number table into control group and combined group, with 75 cases in each group. The control group received oxytocin for prevention of postpartum hemorrhage, and the combined group received oxytocin combined with carbetocin for prevention of postpartum hemorrhage. Comparison were made on postpartum bleeding volume, heart rate difference in postpartum 2 and 24 h, occurrence of postpartum hemorrhage and adverse reactions between the two groups. Results The combined group had obviously better postpartum bleeding volume, heart rate difference in postpartum 2 and 24 h than the control group, and the difference was statistically significant(P<0.05). The combined group had incidence of postpartum hemorrhage as 1.33% and incidence of adverse reactions as 1.33%, which were 10.67% and 9.33% in the control group. The combined group had lower incidence of postpartum hemorrhage and adverse reactions than the control group, and the difference was statistically significant(P<0.05). Conclusion In the prevention of postpartum hemorrhage in vaginal delivery, oxytocin combined with carbetocin shows ideal effect, and it can effectively reduce postpartum volume, stabilize heart rate and lower the incidence of postpartum hemorrhage and adverse reactions.