黄体酮个体化治疗复发性流产的效果评价

Effect evaluation of individualized progesterone therapy for the treatment of recurrent abortion

目的探讨黄体酮个体化治疗复发性流产的效果。方法 90例复发性流产患者,根据治疗方式不同分为对照组(43例)和观察组(47例)。对照组患者给予常规治疗,观察组患者给予黄体酮个体化治疗。观察对比两组患者的黄体酮注射时间、总用药量、流产、早产及围生儿不良结局发生情况。结果观察组的黄体酮注射时间(36.71±6.22)d短于对照组的(43.98±3.83)d,总用药量(1455.82±203.44)mg少于对照组的(1829.68±203.37)mg,差异具有统计学意义(P<0.05)。观察组的流产、早产及围生儿不良结局发生率分别为2.13%、4.26%、0,均明显低于对照组的13.95%、18.60%、13.95%,差异具有统计学意义(P<0.05)。结论采取黄体酮个体化治疗复发性流产,能有效降低患者流产、早产及围生儿不良结局发生率,值得临床推广应用。

Objective To discuss the effect of individualized progesterone therapy for the treatment of recurrent abortion. Methods A total of 90 patients with recurrent abortion were divided by different treatment methods into control group(43 cases) and observation group(47 cases). The control group received conventional therapy, and the observation group received individualized progesterone therapy. Observation and comparison were made on progesterone injection time, total dosage, occurrence of abortion, premature delivery and adverse perinatal outcomes between the two groups. Results The observation group had shorter progesterone injection time as(36.71±6.22) d than(43.98±3.83) d in the control group, and less total dosage as(1455.82±203.44) mg than(1829.68±203.37) mg in the control group. Their difference was statistically significant(P<0.05). The observation group had obviously lower incidence of abortion, premature delivery and adverse perinatal outcomes respectively as 2.13%, 4.26% and 0 than 13.95%, 18.60% and 13.95% in the control group, and their difference was statistically significant(P<0.05). Conclusion Individualized progesterone therapy for recurrent abortion can effectively lower the incidence of abortion, premature delivery and adverse perinatal outcomes, and it is worthy of clinical application.