趋化因子与抑郁症关系的研究进展

The research progress on relationship between depression and chemokines

炎症反应是抑郁症的重要发病机制之一。近年来研究表明,许多抑郁症患者的相应脑区都存在炎症反应,而介导炎症反应的趋化因子在其中发挥着重要的作用。趋化因子也与抑郁症涉及的神经可塑性、单胺类神经递质减少及神经内分泌系统密切相关。该文对近年来趋化因子与抑郁症关系的研究进展进行简要综述,以期为深入了解和治疗抑郁症带来新的启示。

Inflammation is an important mechanism and etiology of depression.In recent years,researchers have demonstrated that many depression patients are with inflammatory reactions in the corresponding brain regions,and simultaneously chemokines play an important role in depression and inflammation.Meanwhile,in the course of depression,chemokines and their receptors are involved in neuroplasticity,the decrease of monoamine neurotransmitters and neuroendocrine system.In this review,in order to further understand and find better treatment of depression,we summarize the recent studies of the relationship between chemokines and depression disorder.