低频重复经颅磁刺激联合文拉法辛治疗难治性抑郁症的疗效分析

Efficacy analysis of low frequency repetitive transcranial magnetic stimulation combined with venlafaxine in the treatment of refractory depression

目的:观察难治性抑郁症(TRD)接受低频重复经颅磁刺激(rTMS)联合文拉法辛治疗的效果。方法:收治TRD患者86例,分为两组各43例。甲组采用文拉法辛治疗,乙组采用rTMS+文拉法辛治疗,比较两组疗效。结果:乙组总有效率为69.8%,高于甲组39.5%,差异有统计学意义(P<0.05)。治疗后,乙组汉密尔顿抑郁量表(HAMD)评分低于甲组,差异有统计学意义(P<0.05)。结论:rTMS联合文拉法辛治疗TRD,疗效显著。

Objective:To observe the effect of low frequency repetitive transcranial magnetic stimulation(rTMS)combined with venlafaxine in the treatment of refractory depression(TRD).Methods:86 patients with TRD were selected,they were divided into the two groups with 43 cases in each group,the group A received venlafaxine treatment and the group B treated by rTMS and venlafaxine.Results:The total effective rate in the group B was 69.8%,which was higher than that in the group A of 39.5%,P<0.05 the difference was significant,and the score of Hamilton Depression Scale(HAMD)in the group B was lower than that in the group A,P<0.05 the difference was significant.Conclusion:rTMS combined with venlafaxine in the treatment of TRD is effective.