低剂量阿司匹林预防子痫前期高危孕妇的疗效

Efficacy of Low-dose Aspirin in the Prevention of Preeclampsia in High-risk Pregnant Women

目的探讨临床中应用低剂量阿司匹林对预防子痫前期高危孕妇的治疗效果。方法选取我科2017年1月—2018年7月收治的子痫前期高危孕妇88例作为研究对象,将其分为两组,分别给予常规治疗、常规治疗联合低剂量阿司匹林,比较两组患者的疗效。结果阿司匹林组治疗后的平均动脉压较参照组低,且24小时尿蛋白低于参照组,血钙水平高于参照组,两组各指标比较,差异具有统计学意义(P <0.05)。与参照组比较,阿司匹林组患者子痫前期发病率明显较少,且分娩孕周明显较长,两组比较,差异具有统计学意义(P <0.05)。两组均无死亡病例且胎儿无死产情况。两组分娩方式比较,差异不具有统计学意义(P> 0.05)。阿司匹林组围生儿结局优于参照组,差异有统计学意义(P <0.05)。结论低剂量阿司匹林对预防高危孕妇子痫前期有较好效果,可改善临床指标,降低子痫前期发病率,安全性较好。

Objective To investigate the clinical effect of low-dose Aspirin in the prevention of preeclampsia in high-risk pregnant women.Methods 88 cases of pregnant women with high risk of preeclampsia admitted to our department from January 2017 to July 2018 were selected as the research objects.They were divided into two groups.They were given routine treatment,routine treatment combined with low-dose aspirin,respectively. The curative effects of the two groups were compared.Results After treatment,the average arterial pressure in aspirin group was lower than that in the control group,and 24-hour urinary protein was lower than that in the control group,and serum calcium level was higher than that in the control group.There was a significant difference between the two groups (P<0.05). Compared with the control group,the incidence of preeclampsia in aspirin group was significantly lower,and the gestational week of delivery was significantly longer,the difference between the two groups was statistically significant (P<0.05).There were no deaths and no stillbirths in both groups.There was no significant difference in delivery mode between the two groups (P>0.05).The perinatal outcome of aspirin group was better than that of control group (P<0.05).Conclusion Low-dose aspirin has a better effect on preventing preeclampsia in high-risk pregnant women,can improve clinical indicators,reduce the incidence of preeclampsia,and has a better safety.