保妇康栓联合LEEP术治疗CIN伴HR-HPV感染的临床价值观察

Clinical value of Baofukang suppository combined with LEEP in the treatment of CIN with HR-HPV infection

目的观察并探究保妇康栓联合宫颈环形电切术(LEEP)治疗宫颈上皮内瘤变(CIN)伴高危型人乳头瘤病毒(HR-HPV)感染的临床价值。方法选择本院收治的CIN伴HR-HPV感染患者104例为研究对象,遵照随机数字表法分为研究组(n=52,给予保妇康栓联合LEEP术治疗)和对照组(n=52,给予LEEP术治疗),比较其术后恢复情况、CIN疗效及HR-HPV清除效果。结果研究组阴道出血时间、出血量、排液量、排液持续时间及创面愈合时间均显著低于对照组(P<0.05);术后6个月,研究组94.23%的CIN疗效治愈率显著高于对照组的80.77%(P<0.05);术后6个月,研究组82.69%的HPV清除率显著高于对照组的59.62%(P<0.05)。结论 CIN伴HR-HPV感染患者于LEEP术后使用保妇康栓能够促进术后恢复,CIN治愈率、HR-HPV清除率高。

Objective To observe and explore the clinical value of Baofukang suppository combined with loop electrosurgical excision procedure (LEEP) in the treatment of cervical intraepithelial neoplasia (CIN) with high-risk human papillomavirus (HR-HPV) infection. Methods A total of 104 cases of patients with CIN and HR-HPV infection treated in the hospital were selected as subjects, and were divided into study group (n=52, given Baofukang suppository combined with LEEP) and control group (n=52, given LEEP) according to the random number table method. The postoperative recovery, CIN efficacy and HR-HPV clearance effects were compared. Results The duration of vaginal bleeding, blood loss, drainage, drainage duration and wound healing time in study group were significantly lower than those in control group (P<0.05). At 6 months after surgery, the cure rate of CIN efficacy in study group was significantly higher than that in control group (94.23% vs 80.77%)(P<0.05). At 6 months after surgery, the HPV clearance rate in study group was significantly higher than that in control group (82.69% vs 59.62%)(P<0.05). Conclusion Baofukang suppository after LEEP in patients with CIN and HR-HPV infection can promote the postoperative recovery, and it has high CIN cure rate and HRHPV clearance rate.