改良根治术在治疗乳腺癌患者中的应用及对患者生活质量的影响

The application of modified radical mastectomy in the treatment of breast cancer and its effect on patients' quality of life

目的研究改良根治术在乳腺癌患者治疗中的应用及对患者生活质量的影响。方法回顾性分析2014年2月至2015年3月接诊的68例乳腺癌患者,其中标准根治术治疗34例(对照组),改良根治术治疗34例(研究组),两组患者术后均接受化疗等后续治疗。参照WHO生活质量评定量表评价患者生活质量,比较两组患者手术相关指标及术后6个月的生活质量。观察两组并发症发生情况及随访3年的生存率、局部复发率及远处转移率等远期疗效。结果治疗后,治疗组手术时间和住院时间均短于对照组,术中出血量少于对照组,两组手术相关指标比较差异具有统计学意义(P<0.05);治疗组生理状态、心理状态、环境情况和社会功能分值均明显高于对照组,两组比较差异具有统计学意义(P<0.05)。治疗组并发症总发生率(5.88%)明显低于对照组(23.52%),两组比较差异具有统计学意义(P<0.05)。两组患者的3年生存率、局部复发率及远处转移率比较差异均无统计学意义。结论改良根治术在保留标准根治术治疗疗效的基础上,改善了乳腺癌患者手术指标和生活质量,减少并发症发生。

Objective To study the application of modified radical mastectomy in the treatment of breast cancer and its effect on the quality of life of patients. Methods A retrospective analysis of 68 cases of breast cancer from February 2014 to March 2015 was made, including 34 cases of standard radical mastectomy (control group) and 34 cases of modified radical mastectomy (study group). Both groups received follow-up treatment such as chemotherapy after operation. The patients' quality of life was evaluated by WHO Quality of Life Scale, and the related indexes of operation and the quality of life 6 months after operation were compared between the two groups. The occurrence of complications, survival rate, local recurrence rate and distant metastasis rate of the two groups were observed. Results After treatment, the operation time and hospitalization time of the treatment group were shorter than those of the control group, and the amount of bleeding during operation was less than that of the control group. There were significant differences in the operation-related indexes between the two groups (P<0.05);the scores of physiological state, psychological state, environmental condition and social function of the treatment group were significantly higher than those of the control group, with significant differences between the two groups (P<0.05). The total incidence of complications in the treatment group (5.88%) was significantly lower than that in the control group (23.52%). There was a significant difference between the two groups (P<0.05). There was no significant difference in 3-year survival rate, local recurrence rate and distant metastasis rate between the two groups. Conclusion Modified radical mastectomy can improve the operative index and quality of life of breast cancer patients and reduce complications on the basis of retaining the curative effect of standard radical mastectomy.