复方甘草酸苷片联合地氯雷他定片和生长因子凝胶治疗面部激素依赖性皮炎临床研究

Clinical Study on Compound Glycyrrhizin Tablets Combined with Desloratadine Tablets and Growth Factor Gel in the Treatment of Facial Hormone Dependent Dermatitis

目的探讨复方甘草酸苷片联合地氯雷他定片和生长因子凝胶治疗面部激素依赖性皮炎(HDD)的临床疗效及安全性。方法选取医院2015年1月至2018年1月收治的面部HDD患者95例,按随机数字表法分为对照组(47例)和治疗组(48例)。两组患者给予地氯雷他定片联合重组牛碱性成纤维细胞生长因子凝胶治疗,治疗组患者加用复方甘草酸苷片治疗。两组患者均连续均治疗12周。结果治疗后,两组患者的主观症状、客观症状及总积分均明显低于治疗前,且治疗组明显低于对照组(P <0. 05);治疗组总有效率为93. 75%,明显高于对照组的78. 72%(χ2=4. 540,P=0. 033 <0. 05);治疗后,两组患者角质层含水量、皮脂含量均明显大于治疗前,经表皮水分丢失量均明显小于治疗前,且治疗组明显优于对照组(P <0. 05);两组患者血清白细胞介素2(IL-2)、干扰素-γ(IFN-γ)、血清IL-4,IL-6水平均明显优于治疗前,且治疗组明显优于对照组(P <0. 05)。不良反应发生率治疗组为12. 50%(6/48),对照组为10. 64%(5/47),组间比较无明显差异(χ2=0. 080,P=0. 777> 0. 05)。结论复方甘草酸苷片联合地氯雷他定片和生长因子凝胶治疗面部HDD的临床疗效显著,可明显改善临床症状,修复皮肤屏障功能,调节Th1/Th2细胞因子,且安全性较好,值得推广。

Objective To investigate the clinical effect and safety of Compound Glycyrrhizin Tablets combined with Desloratadine Tablets and growth factor gel in the treatment of facial hormone dependent dermatitis(HDD).Methods Totally 95 patients with facial HDD admitted to our hospital from January 2015 to January 2018 were divided into the control group(47 cases)and the treatment group(48 cases)according to the random number table method.The patients in the two group were treated with Desloratadine Tablets combined with Recombinant Bovine Basic Fibroblast Growth Factor Gel,on this basis,the patients in the treatment group were treated with Compound Glycyrrhizin Tablets.The patients in the two groups were continuously treated for 12 weeks.Results After treatment,the subjective symptoms,objective symptoms and total scores of the two groups were significantly lower than those before treatment,and those of the treatment group were significantly lower than those of the control group(P<0.05).The total effective rate of the treatment group was 93.75%,which was significantly higher than 78.72%of the control group(χ2=4.540,P=0.033<0.05).After treatment,the water content and sebum content of cuticle in the two groups were significantly higher than those before treatment,the water loss through epidermis was significantly less than that before treatment,and those in the treatment group were significantly better than those in the control group(P<0.05).The levels of serum interleukin-2(IL-2),interferon-γ(IFN-γ),interleukin-4(IL-4)and interleukin-6(IL-6)in the two groups were significantly better than those before treatment,and those in the treatment group were significantly better than those in the control group(P<0.05).The incidence rate of adverse reactions in the treatment group was 12.50%(6/48),that of the control group was 10.64%(5/47),and there was no significant difference between the two groups(χ^2=0.080,P=0.777>0.05).Conclusion Compound Glycyrrhizin Tablets combined with Desloratadine Tablets and growth factor gel are effectively in the treatment of facial HDD,they can significantly improve the clinical symptoms,repair the skin barrier function and regulate Th1/Th2 cytokines,which are safe and worthy of promotion.