血清降钙素原、C-反应蛋白及白细胞介素-6联合检测在全髋关节置换术后感染诊断中的价值

Diagnostic Value of Joint Detection of Serum Procalcitonin,C-reactive Protein and Interleukin-6 in Diagnosis of Infections after Total Hip Arthroplasty

选取2015年1月～2017年12月牡丹江医学院附属红旗医院发生全髋关节置换术后感染的23例患者作为感染组,另外选取同期未发生感染的29例患者作为非感染组。检测并比较两组患者血清降钙素原(PCT)、C-反应蛋白(CRP)及白细胞介素-6(IL-6)水平,并比较不同指标的灵敏度、特异度及曲线下面积(AUC)。检测结果表明:感染组血清PCT、CRP及IL-6水平均显著高于非感染组,差异具有统计学意义(P <0. 05);联合检测血清PCT、CRP及IL-6水平对全髋关节置换术后感染的灵敏度、特异度及AUC均优于单独检测,差异具有统计学意义(P <0. 05)。可见血清PCT、CRP及IL-6联合检测对于诊断全髋关节置换术后感染具有一定的实用价值,应在临床工作中加以推广。

Twenty-three cases of patients with infections after total hip arthroplasty at the affiliated Hongqi hospital to Mudanjiang Medical University from January 2015 to December 2017 were selected as the infection group,and twenty-nine cases of patients with no infections at the same time were selected as the non-infected group. The levels of serum procalcitonin( PCT),C-reactive protein( CRP) and Interleukin-6( IL-6) of the two groups were measured,and the levels of serum PCT,CRP and IL-6 were compared between the two groups,and the sensitivity,specificity and area under the curve( AUC) were compared among the indexes. The results show that the levels of serum PCT,CRP and IL-6 in the infected group are significantly higher than those in the non-infected group,the difference is statistically significant( P < 0. 05);the sensitivity,specificity and AUC of joint detection of serum PCT,CRP and IL-6 in diagnosis of infections after total hip arthroplasty are significant better than that of individual detection,the difference is statistically significant( P < 0. 05). It is concluded that the joint detection of serum PCT,CRP and IL-6 has certain practical value for diagnosis of infections after total hip arthroplasty may be promoted in clinical work.