Livin CMTM3与胃癌的相关性研究

THE RESEARCH OF LIVIN AND CMTM3 GENE EXPRESSION IN GASTRIC CANCER

目的探讨Livin、CMTM3基因与胃癌的关系。方法选择35例胃癌患者作为观察组,另选28例胃炎患者作为对照组。采用PCR方法检测两组Livin、CMTM3基因的表达情况,分析胃癌组织中Livin、CMTM3表达与临床表现之间的关系。结果 Livin基因:观察组的阳性率为51.4%(18/35),对照组为14.3%(4/28),二者比较有统计学意义(χ~2=7.79,P<0.01);CMTM3基因:观察组阳性率为25.7%(9/35),对照组为78.6%(22/28),观察组基因表达低于对照组(χ~2=15.34,P<0.01)。观察组Livin、CMTM3基因表达在组织分化程度方面均有显著差异(P<0.05);CMTM3在淋巴转移方面有显著差异(P<0.05)。结论 Livin、CMTM3基因在胃癌组织中呈异常表达,可能参与了胃癌的发生发展进程。

Objective To study the relationship between Livin gene and CMTM3 gene in the development of gastric cancer. Methods Livin gene and CMTM3 gene in gastric cancer patients were detected respectively by PCR, then compared with gastritis patients. The characteristics of Livin gene and CMTM3 expression in gastric cancer and gastritis were analyzed. Results The positive rate of Livin Gene in gastric cancer patients was 51.4%(18/35), and the control group was 14.3%(4/28).The positive rate of CMTM3 Gene in gastric cancer patients was 25.7%(9/35), and the control group was 78.6%(22/28). There were significant differences about Livin and CMTM3 gene expression in gastric cancer as compared with control group( P <0.01). Livin and CMTM3 gene expression were significantly different in tissue differentiation degree( P <0.05). CMTM3 has significant effects in lymph node metastases( P <0.05). Conclusion Livin and CMTM3 gene in gastric cancer showed aberrant expression,and they may be involved in the progression of gastric cancer, and may play an important role in the development of gastric cancer. Livin and CMTM3 may provide important objective diagnosis and gene therapeutic target in gastric cancer.