摘要
目的:探讨白细胞介素-22(IL-22)在类风湿关节炎中的临床意义。方法:选取类风湿关节炎患者49例(类风湿关节炎组),检测血浆IL-22水平、红细胞沉降率、C-反应蛋白、类风湿因子、抗环瓜氨酸肽抗体,记录患者关节压痛数、关节肿胀数,并计算疾病活动评分(DAS28)。分析IL-22与这些指标的相关性。健康对照组24例采用酶联免疫吸附法检测血浆IL-22。结果:①类风湿关节炎组血浆IL-22为(183.43±14.12)ng·L^(-1),健康对照组为(105.33±11.12)ng·L^(-1),2组比较,差异有统计学意义(P <0.05)。②类风湿关节炎高活动组IL-22为(216.36±25.24)ng·L^(-1),中活动组为(160.17±15.65)ng·L^(-1),与低缓组(136.57±20.34)ng·L^(-1)比较,差异有统计学意义(P <0.05)。③类风湿关节炎患者血浆IL-22水平与红细胞沉降率、关节压痛数、关节肿胀数、类风湿因子、C-反应蛋白及DAS28等指标呈正相关。结论:类风湿关节炎患者血浆IL-22较健康对照组升高,且与类风湿因子、红细胞沉降率、关节肿胀数及DAS28等活动性指标相关。IL-22可能参与了类风湿关节炎的发病过程。
Objective:To investigate the clinical significance of interleukin-22(IL-22)in rheumatoid arthritis.Methods:Forty-nine patients with rheumatoid arthritis(the RA group)were selected.The level of IL-22 in plasma,erythrocyte sedimentation rate,C-reactive protein,rheumatoid factor and anti-CCP antibody were measured.The number of tenderness and swelling of joints were recorded and the disease activity score(DAS28)was calculated.The correlation between IL-22 and these indices was analyzed.The IL-22 in plasma was detected by enzyme-linked immunosorbent assay in 24 healthy controls.Results:① The IL-22 level in the RA group was(183.43±14.12)ng·L^-1,and that in healthy control group was(105.33±11.12)ng·L^-1.There was a significant difference between the two groups(P < 0.05).② IL-22 was(216.36±25.24)ng·L^-1 in the RA high activity group and(160.17±15.65)ng·L^-1 in the RA medium activity group.There was a significant difference compared with the low activity group(136.57±20.34)ng·L^-1(P < 0.05).③ The level of IL-22 in plasma in RA patients were positively correlated with erythrocyte sedimentation rate,joint tenderness,joint swelling,rheumatoid factor,C-reactive protein and DAS28.Conclusion:The level of IL-22 in plasma of RA patients is higher than that in healthy controls,and it is related to rheumatoid factor,erythrocyte sedimentation rate,joint swelling and DAS28.IL-22 may be involved in the pathogenesis of RA.
出处
《风湿病与关节炎》
2019年第4期28-30,49,共4页
Rheumatism and Arthritis
