维生素D对反复呼吸道感染患儿体液免疫功能的改善效果

Improvement of Humoral Immune Function in Children with Recurrent Respiratory Tract Infection by Vitamin D

目的:探讨维生素D对反复呼吸道感染(RRTI)患儿体液免疫功能的改善效果。方法:将116例RRTI患儿均分为治疗组和对照组,对照组采用常规治疗,治疗组在对照组治疗的基础上联合使用阿尔法骨化醇(维生素D前体药物)治疗,治疗3个月后随访12个月;比较两组患儿咳嗽消失时间、喘息消失时间、肺部啰音消失时间、退热时间及随访期内呼吸道感染次数,采用速率散射比浊法测定血清免疫球蛋白(Ig)A、IgM及IgG水平,采用25-(OH) D3试剂盒测定血清25-(OH) D3含量;比较随访结束时两组患儿的治疗效果。结果:治疗组患儿咳嗽、喘息、肺部啰消失时间及退热时间显著短于对照组(P<0.05);治疗后两组患儿呼吸道每年感染次数均较治疗前减少,且治疗组显著少于对照组(P<0.05);治疗后治疗组血清IgA、IgM、IgG及25-(OH) D_3水平较治疗前显著升高,且较对照组升高更明显(P<0.05);治疗组总有效率、治愈率显著高于对照组(P<0.05)。结论:维生素D可有效改善RRTI患儿临床症状,减少感染次数,增强体液免疫功能,疗效显著。

Objective: To explore the effect of improvement of humoral immune function in children(RRTI) with recurrent respiratory tract infection by vitamin D. Methods: A total of 116 children with RRTI were divided into two groups: treatment group and control group.The control group was treated with routine therapy, and the treatment group was treated with alpha ossification alcohol(vitamin D precursor) on the basis of the control group. The treatment group was followed up for 12 months after 3 months of treatment. The cough disappearance time, wheezing disappearance time, lung rale disappearance time, antipyretic time and respiratory tract infection times during the follow-up period were compared between the two groups. The serum levels of(Ig) A, IgM and IgG were measured by rate scattering turbidimetry. The content of 25-(OH) D3 serum was determined by 25-(OH) D3 kit, and the therapeutic effects of the two groups at the end of follow-up were compared. Results: In the treatment group, the cough, the wheezing, the disappearance time of the lung and the time of the fever were significantly shorter than that of the control group(P<0.05). The number of respiratory infections was reduced in the two groups after treatment, and the treatment group was significantly less than that in the control group(P<0.05). After treatment, the levels of serum IgA,IgM,IgG and 25-(OH) D3 in the treatment group were significantly higher than those before treatment, and were more obvious in the treatment group than in the control group(P<0.05). The total effective rate and the cure rate of the treatment group are obviously higher than that of the control(P<0.05). Conclusion: Vitamin D can effectively improve the clinical symptoms, reduce the number of infections, and enhance humoral immune function in children with RRTI.