硫酸镁联合拉贝洛尔对重度妊高症患者血压及血流变指标的影响

Effect of magnesium sulfate combined with labetalol on blood pressure and blood rheological parameters in patients with severe pregnancy-induced hypertension syndrome

目的分析硫酸镁联合拉贝洛尔对重度妊高症患者血压及血流变指标的影响。方法回顾性分析2017年3月至2017年10月我院收治的261例重度妊高症患者的临床资料,根据治疗方法的不同将患者分为对照组(n=103)和观察组(n=158)。对照组患者给予硫酸镁治疗,观察组患者在对照组基础上使用拉贝洛尔治疗。比较两组患者的临床疗效。结果治疗后,两组患者的收缩压、舒张压均降低,且观察组低于对照组(P<0.05)。治疗后,两组患者的24 h尿蛋白定量均降低,且观察组低于对照组(P<0.05)。治疗后,两组患者的血浆粘度、全血粘度、红细胞比容均显著降低,且观察组低于对照组,差异具有统计学意义(P<0.05)。对照组患者的妊娠并发症总发生率为22.33%,高于观察组的13.92%,但差异不具有统计学意义(P>0.05)。结论硫酸镁联合拉贝洛尔可显著降低患者的血压,改善血流变指标,具有较高的安全性及临床应用价值。

Objective To analyze the control effect of magnesium sulfate combined with labellol on blood pressure and blood rheological parameters in patients with severe pregnancy-induced hypertension syndrome. Methods The clinical data of 261 patients with severe pregnancy-induced hypertension syndrome admitted in our hospital from March 2017 to October 2017 were retrospectively analyzed. The patients were divided into control group(n=103) and observation group(n =158) according to the different treatment methods. The patients in the control group were treated with magnesium sulfate, while the patients in the observation group were treated with labellol on the basis of the control group. The clinical treatment effects between the two groups were compared. Results After treatment, the systolic and diastolic blood pressure of the two groups decreased, and those in the observation group were lower than the control group(P<0.05). After treatment,the 24-hour urinary protein quantification of the two groups decreased, and that in the observation group was lower than the control group(P<0.05). After treatment, the plasma viscosity, whole blood viscosity and erythrocyte specific volume of the two groups significantly decreased, and those in the observation group were lower than the control group(P<0.05). The total incidence of pregnancy complication in the control group was 22.33%, which was higher than 13.92% in the observation group, but the difference was not statistically significant(P >0.05). Conclusion Magnesium sulfate combined with labetalol can significantly reduce the blood pressure and improve the blood rheological parameters of patients, with high safety and significant clinical value.