他汀类药物预防蒽环类药物心脏毒性的研究进展

Research progress on preventing the cardiotoxicity of anthracyclines by statins

他汀类药物是一种羟甲基戊二酰辅酶A还原酶抑制剂(AHMG-CoA还原酶抑制剂),是目前临床应用广泛的降脂药物,对心血管作用尤为重要。近年来,国内外多项研究认为他汀类药物可以预防蒽环类药物引起的心脏毒性,并提出他汀类药物可通过抗炎和抗氧化机制发挥有益的多效心血管效应,从而起到心脏保护作用。他汀类药物的非调脂作用得到了广泛关注。本文就他汀类药物在预防蒽环类药物心脏毒性方面的研究进展进行综述。

Statin is a hydroxymethylglutaryl coenzyme A reductase inhibitor(AHMG-CoA reductase inhibitor),which is a widely used lipid-lowering drug in clinical practice and is particularly important for cardiovascular effects. In recent years, many studies at home and abroad have concluded that statins can prevent cardiotoxicity caused by anthracyclines, and have suggested that statins can exert beneficial multi-effect cardiovascular effects through anti-inflammatory and antioxidant mechanisms, thereby playing a cardioprotective role. The non-lipiding effect of statins has received wide attention. This article reviews the research progress of statins in preventing the cardiotoxicity of anthracyclines.