骨伤手法联合腹针治疗颈型颈椎病的效果及对患者IL-6、TNF-α和IL-1β的影响

Effects of bone injury manipulation combined with abdominal acupuncture on IL-6,TNF-α and IL-1β in patients with cervical spondylopathy

目的探讨骨伤手法联合腹针治疗颈型颈椎病的效果及对患者白介素-6(interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白介素-1β(interleukin-1β,IL-1β)的影响。方法选取2014年4月至2017年4月治疗的颈型颈椎病80例患者,随机分为对照组和观察组,每组40例。对照组患者给与中医骨伤手法进行治疗,1次/d,治疗2周。观察组患者在对照组患者治疗的基础上给与腹针治疗。每天行针1次,每周5次,治疗2周,共行针10次。酶联免疫吸附法检测血清中IL-6、IL-1β的水平,电化学发光免疫分析法检测血清TNF-α的水平,治疗前后对患者疼痛评分,对疗效效果进行判断,统计2组患者满意度情况。结果颈型颈椎病患者血清中IL-6、TNF-α、IL-1β水平与病程和治疗前疼痛评分有关。治疗后,观察组患者血清中IL-6、TNF-α、IL-1β的水平较对照组低,差异有统计学意义(P<0.05)。观察组患者的评分小于对照组,差异有统计学意义(P<0.05)。观察组患者的总有效率为97.50%显著高于对照组的85.00%,差异有统计学意义(P<0.05)。观察组患者的总体满意度显著高于对照组,差异有统计学意义(P<0.05)。结论骨伤手法联合腹针治疗颈型颈椎病的疗效显著,值得临床推广。

Objective To investigate the effects of bone injury manipulation combined with abdominal acupuncture on interleukin-6 (IL-6), tumor necrosis factor-α(TNF-α), interleukin-1β(IL-1β) in patients with cervical spondylopathy. Methods A total of 80 patients with cervical spondylopathy who were treated in our hospital from April 2014 to April 2017 were randomly divided into control group ( n =40) and observation group ( n =40).The patients in control group were treated by traditional Chinese medicine for bone injury,once a day for 2 weeks,however,the patients in observation group,on the basis of control group,were treated by abdominal acupuncture once a day,5 times a week,for 2 weeks.The serum levels of IL-6 and IL-1β were detected by enzyme linked immunosorbent assay (ELISA),and serum levels of TNF-α were detected by electrochemiluminescence immunoassay.Moreover the pain scores before and after treatment,and curative effects and satisfaction degree of patients were observed and compared between the two grousp. Results The serum levels of IL-6,TNF-α,IL-1 and β in patients with cervical spondylopathy were correlated with the duration of disease and the pain scores before treatment.After treatment,the serum levels of IL-6,TNF-α and IL-1β in the observation group were significantly lower than those in control group ( P <0.05).After treatment,the scores in observation group were significantly lower than those in control group ( P <0.05).The total effective rate in observation group was 97.50%,which was significantly higher than that (85.00%) in control group ( P <0.05).Moreover the overall satisfaction degree in observation group was significantly higher than that in control group ( P <0.05). Conclusion The bone injury manipulation combined with abdominal acupuncture is effective in treating cervical spondylopathy,and it is worthy of clinical promotion.