氟比洛芬酯对三叉神经痛静息态功能磁共振成像低频振荡振幅的影响

Effect of Flurbiprofen Axetil on Low-frequency Fluctuation Amplitude of Resting-state Functional Magnetic Resonance Imaging in Trigeminal Neuralgia

目的采用静息态功能磁共振成像(fMRI)技术和低频振荡振幅(ALFF)方法,探讨三叉神经痛患者给予氟比洛芬酯后的脑功能变化特点。方法用1.5T磁共振成像仪采集20例三叉神经痛患者给予氟比洛芬酯治疗前、后的静息态fMRI数据。采用统计参数图和数据处理工具箱脑成像分析软件对静息态fMRI数据进行预处理,然后用ALFF分析比较氟比洛芬酯治疗前后大脑自发性活动的低频振荡振幅的差异。结果给予氟比洛芬酯注射液后的患者疼痛强度视觉模拟评分低于给药前,疼痛有明显缓解(P=0.000)。在静息状态下给予氟比洛芬酯注射液后的患者与给药前相比,其右背外侧前额叶、双侧内侧前额叶和右中扣带回区域的ALFF值均降低(P=0.000)。结论氟比洛芬酯的镇痛作用存在中枢作用机制,抑制因为慢性疼痛刺激引起的脑功能活动异常部位,从而减低疼痛,但具体的中枢作用机制还需要进一步研究和探讨。

Objective To observe the changes of brain function in patients with trigeminal neuralgia after administration of flurbiprofen axetil by using the resting-state functional magnetic resonance imaging(fMRI)and based on the amplitude of low-frequency fluctuation(ALFF). Methods Resting fMRI data of 20 patients with trigeminal neuralgia before and after treatment with flurbiprofen axetil were collected by 1.5T magnetic resonance imaging system.The resting fMRI data were pretreated by Statistical Parametric Mapping and DPABI(a toolbox for Data Processing and Analysis for Brain Imaging)software,and the difference of low-frequency oscillation amplitude of brain spontaneous activity before and after treatment with flurbiprofen axetil was analyzed by ALFF. Results The Visual Analogue Scale of pain intensity after flurbiprofen axetil injection was significantly lower than that before administration,and the pain relieved significantly( P =0.000).The ALFF values of right dorsolateral prefrontal lobe,bilateral medial prefrontal lobe,and right middle cingulate gyrus in patients treated with flurbiprofen axetil at rest were significantly lower than those before administration( P =0.000). Conclusions The analgesic effect of flurbiprofen axetil is exerted on the central system.This agent can inhibit the abnormal brain function caused by chronic pain stimulation and thus reduce pain.However,the specific mechanism needs further investigations.