心力衰竭合并高尿酸血症药物治疗的病例报告及文献分析

Drug therapy of the patients with heart failure and hyperuricemia:case reports and literature analysis

目的:探讨心力衰竭合并高尿酸血症患者的药物治疗方案。方法:分析临床药师参与的心力衰竭合并高尿酸血症患者的药物治疗过程,并进行相关文献分析。结果和结论:心力衰竭与高尿酸血症之间有相互影响,选择适宜的药物可以使患者获益更多。高尿酸血症治疗药物中,非甾体类抗炎药对疼痛缓解和心血管的影响不同,别嘌醇可以降低心血管不良事件发生率。合理选择心衰治疗药物可以降低尿酸水平,从而减轻高尿酸对心血管的影响并减少痛风等不良事件。

Objective : To explore the drug treatment regimen for patients with heart failure complicated with hyperuricemia. Methods : Clinical pharmacists participated in the drug treatment of the patients with heart failure complicated with hyperuricemia,and related literature was reviewed and analyzed. Results and Conclusion : There were interactions between heart failure and hyperuricemia.The choice of right drugs could be more beneficial to patients.In the treatment of hyperuricemia,various non-steroidal anti-inflammatory drugs had different effects on pain relief and cardiovascular system. Allopurinol could reduce the incidence of cardiovascular adverse events.Rational choice of drugs for the treatment of heart failure could reduce the level of uric acid, and subsequently reduce the impact of high uric acid on cardiovascular system and the rate of such adverse events as gout.