炎症性肠病中的自噬异常与中药干预研究进展

Abnormal regulation of autophagy in inflammatory bowel disease and the intervention of traditional Chinese medicine

自噬(autophagy)是由溶酶体介导的细胞程序性降解途径,对维持细胞的稳态,清除胞内毒性物质和代谢能量的平衡具有重要的意义。研究表明自噬异常是炎症性肠病(inflammatory bowel disease,IBD)发生、发展的重要机制,与炎症反应的失调、病原菌侵袭和肠道黏膜的修复障碍密切相关。深入认识自噬调节在IBD防治中的价值对于优化现有治疗策略具有重要意义。本文基于中药在IBD防治中的应用现状,从自噬调节的角度分析了相关中药及其活性成分的作用机制和应用前景,并对相关研究存在的问题和发展趋势进行了初步探讨。

Autophagy is a lysosome-mediated cell-programmed degradation pathway that plays an important role in maintaining cell homeostasis, eliminating intracellular toxic substances and the balance of metabolic energy. Research shows that autophagy is closely related to the dysregulation of inflammatory immune response, pathogen invasion and the repair of intestinal mucosa, and is an important mechanism of inflammatory bowel disease (IBD). These findings are important for understanding the mechanisms of IBD and optimizing existing treatment strategies. In this review, the commonly used traditional Chinese medicines for IBD treatment were summarized from the perspective of autophagy regulation. The implications of autophagy regulation on the mechanism of research related Chinese medicine ingredients and the problems and development trends of related research were discussed.