脾脏上皮样血管内皮瘤一例并文献分析

A case of splenic epithelioid hemangio endothelioma

目的探讨脾脏上皮样血管内皮瘤的临床病理学特征。方法对2013年7月至2018年7月嘉兴市第一医院收治的1例脾脏上皮样血管内皮瘤的临床表现、组织学形态及免疫表型进行分析,并复习相关文献。结果患者无症状于体检时CT检查发现,行脾切除术。术后肿瘤组织镜检下表现为上皮样的肿瘤细胞呈条索样或巢团状分布,形成含有红细胞的管腔或空泡样结构,部分区域伴有黏液变性。肿瘤细胞免疫组化表达结果:CD31(+)、CD34(+)、FIL-1(+)、Ki67(+,10%)。结论脾脏上皮样血管内皮瘤罕见,熟知其临床病理学特征及免疫表型有助于准确诊断。

Objective To explore the clinicopathological features of splenic epithelioid hemangio endothelioma. Methods The clinical manifestations,histological features and immunophenotyping of a case of splenic epithelioid hemangio endothelioma were analyzed,and with related literatures being reviewed. Results Microscopically,this case presented stripe-like or nest-like distribution of epithelioidtumor cells,and the formation of lumen or vacuole-like structure containing red blood cells,and myxoid degeneration was observed in some areas.Immunohistochemical expression of tumor cells:CD31(+),CD34(+),FIL-1(+),Ki67(+,10%). Conclusions The splenic epithelioid hemangio endotheliomais rare and familiarity with its clinicopathological features.Immunophenotyping is helpful for accurate diagnosis.