紫癜基础方治疗儿童皮肤型过敏性紫癜疗效观察

Observation on curative effect of purpura basic prescription in the treatment of children with cutaneous allergic purpura

目的观察紫癜基础方治疗儿童皮肤型过敏性紫癜的临床疗效。方法选择2016年8月至2018年8月江西中医药大学附属医院收治的皮肤型过敏性紫癜患儿120例为研究对象,随机分为观察组和对照组各60例。观察组采用紫癜基础方治疗,对照组使用10%葡萄糖酸钙注射液、复方甘草酸苷注射液、西米替丁注射液、氯雷他定颗粒等常规治疗药物。以2周为1个疗程。治疗2周后,观察两组临床疗效、紫癜消退时间,并随访3个月,观察两组发生肾脏损害的情况。结果治疗2周后两组临床总有效率比较差异无统计学意义(P>0.05)。观察组紫癜平均消退时间为(5.56±2.03)d,显著少于对照组(8.12±1.77)d,差异有统计学意义(P<0.05)。在3个月的随访期内,观察组肾脏损害发生率显著低于对照组,差异有统计学意义(P<0.05)。结论紫癜基础方治疗儿童皮肤型过敏性紫癜疗效满意,尤其紫癜消退时间疗效显著,且有较好的远期预后,能减少患儿的肾脏损害。

Objective To observe the clinical effect of purpura basic prescription in the treatment of cutaneous allergic purpura in children. Methods A total of 120 children with cutaneous allergic purpura admitted to the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine from August 2016 to August 2018 were randomly divided into observation group and control group with 60 cases in each group. The observation group was treated with basic prescription for purpura, while the control group was treated with routine drugs including 10% calcium gluconate injection, compound glycyrrhizin injection, cimetidine injection and loratadine granules, 2 weeks as a course of treatment. After 2 weeks of treatment, the clinical efficacy and the time of purpura subsidence of the two groups were observed;the patients were followed up for 3 months to observe the occurrence of kidney damage in the two groups. Results There was no significant difference in the total effective rate between the two groups after 2 weeks of treatment( P >0.05). The average time of purpura subsidence in the observation group was (5.56±2.03) days, which was significantly shorter than that in the control group (8.12±1.77) days, and the difference was statistically significant( P <0.05). During the 3-month follow-up period, the incidence of kidney damage in the observation group was significantly lower than that in the control group( P <0.05). Conclusion The therapeutic effect of purpura basic prescription on children with cutaneous allergic purpura is satisfactory;in particular,the time of purpura subsidence is significantly short. It has a good long-term prognosis and can reduce the renal damage of children.