血清VDBP、IL-8、sTWEAK与尿VDBP早期诊断糖尿病肾病的价值

The Value of Serum VDBP,IL-8,sTWEAK and Urine VDBP in Early Diagnosis of Diabetic Nephropathy

糖尿病肾病(DN)是糖尿病最常见、最严重的并发症之一。确切发病机理较复杂,目前尚未阐明。传统的DN诊断标记物为:血清尿素氮、肌酐、尿蛋白、肾小球滤过率等,目前临床中DN患者多数因未及时干预血糖波动或治疗不当可致终末期肾病,导致肾脏病理损害不可逆,并大幅提高医疗费用,故对于早期诊断DN挑战很大。目前研究发现存在相关生物标记物:血清VDBP、IL-8、sTWEAK与尿VDBP皆有可能成为DN早期诊断的可靠检验指标。本文就上述生物标志物早期诊断DN进展做一综述。

Diabetic nephropathy (DN) is one of the most common and serious complications of diabetes. The exact pathogenesis is more complicated and has not yet been elucidated. The traditional DN diagnostic markers are: serum urea nitrogen, creatinine, urinary protein, glomerular filtration rate, etc. At present, most of the DN patients in the clinic are not affected by blood glucose fluctuations or improper treatment can cause end-stage renal disease, leading to renal pathological damage. It is irreversible and greatly increases medical expenses, so it is very challenging for early diagnosis of DN. At present, it is found that there are related biomarkers: serum VDBP, IL-8, sTWEAK and urinary VDBP may be reliable indicators for early diagnosis of DN. This article reviews the progress of early diagnosis of DN in biomarkers.