尤瑞克林在不同TOAST分型急性脑梗死临床治疗中应用效果分析

Analysis of the effect of Eurekline in the treatment of Acute Cerebral Infarction with different TOAST Classification

目的 探究对不同TOAST分型急性脑梗死患者实施尤瑞克林的疗效,为临床提供指导。方法 随机将2015年1月-2018年1月我院78例急性脑梗死患者分为观察组(39例,应用常规治疗+尤瑞克林治疗)、对照组(39例,应用常规治疗)。对比2组患者的临床疗效、神经功能缺损(NIHSS)评分、改良残障水平评定量表(mRS)评分及不良反应发生率。结果 观察组患者治疗后NIHSS评分(20.02±2.12)分、mRS评分(1.52±0.42)分,<对照组(23.36±2.78)分、(2.04±0.39)分,P<0.05;观察组患者总有效率(94.87%)>对照组(76.92%),P<0.05;观察组LAA、CE、SAA型改善幅度明显优于对照组,且LAA型改善效果较CE型、SAA型更佳,P<0.05;用药期间,观察组2例患者出现血压下降,2例出现恶心呕吐症状,经对症治疗后恢复,其余患者均未出现不良反应。结论 对不同TOAST分型急性脑梗死患者实施尤瑞克林具有较好的效果,尤其对LAA型患者,更有助于改善神经功能,且用药安全性较好,值得各医疗机构实践。

Objective To explore the efficacy of eucrine in patients with acute cerebral infarction according to different TOAST classification, and to provide guidance for clinical practice. Methods Seventy-eight patients with acute cerebral infarction from January 2015 to January 2018 were randomly divided into observation group (39cases) and control group (39cases). The clinical efficacy,(NIHSS) score of neurological impairment,(mRS) score of modified disability rating scale and incidence of adverse reactions were compared between the two groups. Results After treatment, the NIHSS score (20.02 ±2.12) of the observation group (1.52 ±0.42) was lower than that of the control group (23.36 ±2.78),(2.04 ±0.39),P<0.05, the total effective rate of the observation group (94.87%) was higher than that of the control group (76.92%)(P<0.05), the improvement of LAA,CE,SAA type in the observation group was significantly better than that in the control group (P<0.05). The improvement effect of LAA type was better than that of CE type (P<0.05). During the treatment period, 2 patients in the observation group had the symptoms of nausea and vomiting and recovered after symptomatic treatment. No adverse reactions were found in the other patients. Conclusion Eucrine has a good effect on patients with acute cerebral infarction according to different TOAST classification, especially for patients with LAA type, it is more helpful to improve nerve function, and the safety of medication is better, which is worthy of practice in various medical institutions.