125例早期宫颈癌患者术后预后的相关因素分析

Analysis the Postoperative Prognostic Factors of 125 Patient with the Early Cervical Cancer

目的 探讨早期宫颈癌患者术后预后的相关因素。方法 选择确诊的宫颈癌术后患者(ⅠA2-ⅡA期)125例,对研究对象的年龄、FIGO分期、肿瘤大小、病理类型、肿瘤组织分化程度、脉管浸润、肿瘤浸润深度、淋巴结转移、宫旁浸润、术后边缘及术后辅助治疗等可能的预后影响因素进行单因素和(或)多因素分析。结果 125例宫颈癌术后患者中有24例死亡,全组的5年总生存率(5-yearSR)为80.80%。单因素分析结果显示FIGO分期、组织类型、肿瘤浸润深度、有无盆腔淋巴结转移、肿瘤大小、宫旁浸润及术区边缘对患者5年生存率的影响有统计学意义。多因素分析结果显示FIGO分期、组织类型、肿瘤浸润深度是影响宫颈癌术后5-yearSR的独立因素。结论 FIGO分期、组织类型、肿瘤浸润深度、有无盆腔淋巴结转移、肿瘤大小、宫旁浸润及术区边缘是影响宫颈癌术后5年生存率的临床病理因素。其中FIGO分期、组织类型、肿瘤浸润深度是影响宫颈癌术后5年生存率的独立因素。

Objective To investigate the postoperative prognostic factors of women with the early cervical cancer. Methods A retrospective study of cervical cancer patients is 125 cases. We analyzed the clinical data of each patient such as age, FIGO stage, the size of primary tumor, pathlogical type, tumor differentiation degree,the lymphatic vascular invasion, depth of muscular invasion, the lymph node metastasis , uterine tissue infiltration, the edge of surgical area, postoperative adjuvant therapy modality and evaluated survival influencing factors. Results There were 24 patients died in the whole group (125 patients). The 5-year overall survival rate 80.80%. Univariate analysis showed that FIGO stage, pathlogical type, tumor depth of muscular invasion, the lymph node metastasis, the size of primary tumor, uterine tissue infiltration, the edge of surgical area all influent the postoperative 5-year survival rate of cervical carcinoma. Multifactor analysis showed that FIGO stage, pathlogical type and tumor depth of muscular invasion were independent influence factors to the postoperative 5-year survival rate of cervical carcinoma. Conclusion The factors such as FIGO stage, pathlogical type, tumor depth of muscular invasion, the lymph node metastasis, the size of primary tumor, uterine tissue infiltration and the edge of surgical area had significant impact on the patient,s prognosis. And FIGO stage, pathlogical type and tumor depth of muscular invasion were independent influence factors to the prognosis of cervical carcinoma.