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追求乙型肝炎临床治愈的适合人群与策略

Therapeutic strategy for serum HBsAg clearance in suitable population of chronic hepatitis B
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摘要 近期,国内外有关乙型肝炎防治指南[1-4]都将血清HBsAg清除或血清学转换作为慢性乙型肝炎(chronic hepatitis B,CHB)治疗的理想终点。2015年,我国发布的慢性乙型肝炎防治指南也提出了“临床治愈”的观点:即“持续病毒学应答且HBsAg阴转或伴有抗-HBs阳转、血清丙氨酸氨基转移酶(alanine aminotransferase,ALT)正常、肝组织学轻微或无病变”,并提出在治疗过程中,对于部分适合的患者应尽可能追求临床治愈[2]。
作者 王晓晓 陈新月 Wang Xiaoxiao;Chen Xinyue(International Medical Cantre,You’an Hospital,Affiliated to Capital Medical University,Beijing 100069)
机构地区 首都医科大学附属北京佑安医院国际医疗部
出处 《实用肝脏病杂志》 CAS 2019年第3期309-312,共4页 Journal of Practical Hepatology
基金 "十三五"国家科技重大专项课题(编号:2017ZX10202201/2017ZX10201021-001-008/2017ZX10302201) 首都临床特色应用研究与成果推广项目(编号:Z161100000516018/Z151100004015181) 首都卫生发展科研专题项目(编号:首发2016-1-2183)
关键词 慢性乙型肝炎 HBsAg清除 适合人群 治疗策略 长效干扰素 Hepatitis B HBsAg clearance Suitable population Treatment strategy Pegylated interferon-α
分类号 R512.62 [医药卫生—内科学]
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  • 2European Association for the Study of the Liver.EASL Clinical Practice Guidelines: Management of chronic hepatitis B virus infection[J]. Journal of Hepatology . 2012 (1)
  • 3Chia-Ming Chu,Shao-Jen Hung,Justin Lin,Dar-In Tai,Yun-Fan Liaw.Natural history of hepatitis b e antigen to antibody seroconversion in patients with normal serum aminotransferase levels[J].The American Journal of Medicine.2004(12)
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实用肝脏病杂志
2019年 第3期

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