儿童营养性维生素D缺乏性佝偻病合并缺铁性贫血的临床治疗分析

Clinical analysis of children with nutritional vitamin D deficiency rickets combined with iron deficiency anemia

目的探讨儿童营养性维生素D缺乏性佝偻病合并缺铁性贫血的临床治疗。方法纳入我院2017年8月～2018年9月收治的88例儿童营养性维生素D缺乏性佝偻病合并缺铁性贫血患儿。按随机数字表分组,常规治疗组采取常规补充维生素D和补铁治疗,综合治疗组则采取综合治疗。比较常规治疗组、综合治疗组临床效果、缺铁性贫血纠正的时间、住院时间;治疗前后患儿营养指标、血红蛋白水平;副反应。结果综合治疗组总有效率为93.18%,常规治疗组为68.18%,差异有统计学意义(χ~2=8.212,P<0.05)。综合治疗组副反应与常规治疗组比较,无明显差异(χ~2=0.000,P>0.05);综合治疗组缺铁性贫血纠正的时间、住院时间分别为(8.11±1.21)d、(13.13±0.78)d,常规治疗组分别为(12.44±2.21)d、(18.23±1.54)d,综合治疗组明显优于常规治疗组,差异有统计学意义(t=6.801、6.012,P<0.05)。治疗后综合治疗组营养指标ALB、TP、血红蛋白水平分别为(35.01±5.23)g/L、(64.58±8.11)g/L、(92.19±2.22)mg/L,显著优于常规治疗组的(32.34±4.21)g/L、(61.11±7.12)g/L、(79.23±2.25)mg/L,差异有统计学意义(t=9.073、10.733、15.872,P<0.05)。结论综合治疗儿童营养性维生素D缺乏性佝偻病合并缺铁性贫血效果理想,可有效纠正贫血,改善血红蛋白和营养指标。

Objective To explore the clinical treatment of children with nutritional vitamin D deficiency rickets combined with iron deficiency anemia.Methods A total of 88 children with nutritional vitamin D deficiency rickets and iron deficiency anemia in our hospital from August 2017 to September 2018 were included.Patients were randomized into two groups according to random numbers.The conventional treatment group was given conventional vitamin D supplementation and iron supplementation,while the comprehensive treatment group was given comprehensive treatment.The therapeutic effects of the two groups,the time of correction of iron deficiency anemia,and the length of hospital stay were compared.The nutritional indicators and hemoglobin levels of the children before and after treatment were compared.The incidence of side effects was compared between the two groups.Results The effective rate of treatment in the comprehensive treatment group was 93.18%,which was significantly higher than that in the conventional treatment group(68.18%),the difference was statistically significant(χ^2=8.212,P<0.05).There was no significant difference in the incidence of side effects between the two treatment groups(χ^2=0.000,P>0.05).The correction time of iron deficiency anemia and hospitalization time in the comprehensive treatment group were(8.11±1.21)d and(13.13±0.78)d,respectively,which were significantly shorter than those of the conventional treatment group[(12.44±2.21)d,and(18.23±1.54)d],the difference was statistically significant(t=6.801,6.012,P<0.05).After treatment,the nutritional indicators of ALB,TP and hemoglobin were(35.01±5.23)g/L,(64.58±8.11)g/L,and(92.19±2.22)mg/L in the comprehensive treatment group,which were higher than those of the conventional treatment group[(32.34±4.21)g/L,(61.11±7.12)g/L,and(79.23±2.25)mg/L],the difference was statistically significant(t=9.073,10.733,and 15.872,respectively,P<0.05).Conclusion Comprehensive treatment is effective in children with nutritional vitamin D deficiency rickets combined with iron deficiency anemia,which can effectively correct anemia,and improve hemoglobin and nutritional indicators.