长期小剂量罗红霉素联合氨溴索治疗支气管扩张症对患者痰量、肺功能及呼吸困难评分影响分析

Effect of Long-term Low-dose Roxithromycin Combined with Ambroxol in the Treatment of Bronchiectasis, Lung Function, and Dyspnea Scores in Patients

目的:探讨长期小剂量罗红霉素联合氨溴索治疗支气管扩张症对患者痰量、肺功能及呼吸困难评分影响。方法:2016年1月～2018年1月,随机选取某院收治的支气管扩张症患者90例作为研究对象,根据其入院序号奇偶数按比例(1∶1)划分为对照组和观察组,每组患者45例,对照组给予氨溴索治疗,观察组在此基础上实施长期小剂量罗红霉素治疗,观察对比两组患者治疗前后痰量、呼吸困难评分和肺功能各项指标。结果:治疗前两组患者痰量、呼吸困难评分组间比较差异无统计学意义;治疗1个月后两组患者上述指标均明显提升,且观察组痰量少于对照组,呼吸困难评分低于对照组,P<0.05;治疗前两组患者FEV1、FVC、FEV1/FVC、PEF组间比较差异无统计学意义,P>0.05;治疗1个月后两组患者上述指标均明显提升,且观察组均高于对照组,P<0.05。结论:在支气管扩张症治疗中,长期小剂量罗红霉素联合氨溴索治疗效果理想,患者肺功能各项指标趋于正常,痰多、呼吸困难等症状改善,推荐推广。

Objective:To investigate the effect of long-term low-dose roxithromycin combined with ambroxol in the treatment of bronchiectasis on sputum volume,lung function,and dyspnea scores.Methods:90 patients with bronchiectasis admitted to a hospital from January 2016 to January 2018 were randomly selected as the study subjects,and were divided into control group and observation group according to their odds and even number of admissions (1∶1).45 patients in the control group were treated with ambroxo.The observation group was treated with long-term low-dose roxithromycin.Observed and compared the sputum volume,dyspnea score and lung function index before and after treatment in the two groups.Results:Before treatment,there was no significant difference between the two groups in terms of sputum volume and dyspnea scores.After one month of treatment,the above indicators of both groups were significantly improved.T The sputum volume of the observation group was less than that of the control group,and the dyspnea score was lower than that of the control group ( P <0.05).There was no significant difference in FEV1,FVC,FEV1/FVC,and PEF between the two groups before treatment ( P >0.05).After 1 month of treatment,the above indicators were significantly improved in both groups,and the observation group was higher than the control group ( P <0.05).Conclusion:In the treatment of bronchiectasis,the long-term low-dose roxithromycin combined with ambroxol has a satisfactory therapeutic effect.The lung function indexes of the patients tend to be normal,the symptoms of paralysis,dyspnea and other symptoms are improved.