羧基改性的聚酰胺——胺/纳米羟基磷灰石的制备和表征

Preparation and characterization of carboxyl modified polyamide-amine/nano-hydroxyapatite

目的:制备和表征羧基改性的聚酰胺—胺/纳米羟基磷灰石(PAMAM-COOH/n-HAP)复合材料,并探索其合成时的最佳质量比。方法:通过水热合成法制备不同质量比[m(PAMAM-COOH):m(n-HAP)]的PAMAM-COOH/n-HAP复合材料,利用傅里叶变换红外光谱、透射电镜以及热重分析对其化学信息、形貌和PAMAM-COOH结合到纳米羟基磷灰石上的量进行表征。结果:不同质量比[m(PAMAM-COOH):m(n-HAP)]均可成功制备PAMAM-COOH/n-HAP复合材料,且PAMAMCOOH/n-HAP上PAMAM-COOH涂层厚度不一,其中质量比为1∶4时的厚度为(26.648±1.035)nm,明显高于其它各质量比的厚度(P<0.05),质量比为1∶2时厚度最小,仅为(6.620±0.501)nm。结论:成功制备不同质量比的PAMAM-COOH/n-HAP复合材料,且PAMAM-COOH/n-HAP的最佳质量比为1∶4。

Objective: To prepare and character carboxyl modified polyamide-amine dendrimers/nano-hydroxyapatite (PAMAM-COOH/n-HAP) composites and explore the optimum mass ratio. Methods: Prepare different mass ratiosm [m(PAMAM-COOH):m(n-HAP)] of PAMAM-COOH/n-HAP by hydrothermal synthesis method.Fourier transform infrared spectroscopy,transmission electron microscopy and thermogravimetric analysis were used to verify their chemical information,morphology and the amount of PAMAM-COOH bound to nano-hydroxyapatite. Results: PAMAM-COOH/n-HAP composites with different mass ratios were successfully prepared,and the thickness of PAMAM-COOH coating on PAMAM-COOH/n-HAP was different.The thickness of PAMAM-COOH coating was 26.648 ±1.035 nm,when the mass ratio was 1∶4.It was significantly higher than that of other mass ratios (P<0.05).When the mass ratio was 1∶2,the thickness was the smallest,which was only 6.620±0.501 nm. Conclusion: The optimum mass ratio of PAMAM-COOH/n-HAP composites is 1∶4.