尼尔雌醇联合甲硝唑栓治疗萎缩性阴道炎临床疗效

Clinical observation of nylestriol combined with metronidazole suppository in patients with atrophic vaginitis

目的:考察尼尔雌醇联合甲硝唑栓治疗萎缩性阴道炎的疗效。方法:选取本院2017年4月—2018年12月收治的118例萎缩性阴道炎患者,随机分为观察组和对照组各59例。对照组采用甲硝唑栓,3 g/次,1次/d,治疗1周后停药;观察组在对照组基础上加用尼尔雌醇口服,每2周1次,首次用药4 mg,然后改为2 mg/次,疗程12周。疗程结束后比较两组患者临床疗效以及治疗前后阴道pH值、阴道清洁度、阴道表层细胞百分比。结果:治疗后观察组阴道pH值改善优于对照组(P <0. 05);两组患者治疗前后阴道清洁度均有改善,治疗后观察组阴道清洁度改善优于对照组(P <0. 05);两组患者治疗前后子宫内膜厚度变化不明显,无统计学意义(P> 0. 05);两组患者治疗后阴道表层细胞百分比均有增加(P <0. 05或0. 01),治疗后观察组阴道表层细胞百分比增加优于对照组(P <0. 05);观察组总有效率为88. 14%,对照组为72. 88%,差异有统计学意义(P <0. 05)。结论:尼尔雌醇联合甲硝唑栓治疗萎缩性阴道炎临床疗效可靠,可有效改善阴道清洁度,增加阴道内上皮细胞,降低阴道pH值,可在临床应用。

Objective: To investigate the efficacy of nylestriol combined with metronidazole suppository in the treatment of atrophic vaginitis. Methods: A total of 118 patients with atrophic vaginitis from April 2017 to December 2018 were enrolled and randomly divided into observation group and control group. The control group was treated with metronidazole suppository, 3 g/time, once a day, and stopped after 1 week of treatment. The observation group was treated with nylestriol orally once every 2 weeks on the basis of the control group, and the first dose was 4 mg/time, then changed 2 mg/time for 12 weeks. After the end of the treatment, the clinical efficacy of two groups and the vaginal pH, vaginal cleanliness, and percentage of vaginal surface cells were compared before and after treatment. Results: After treatment, the vaginal pH of the observation group was better than that of the control group (P <0.05). The vaginal cleanliness of both groups was improved before, and the vaginal cleanliness of the observation group was better than that of the control group after treatment. There was no significant difference in endometrial thickness between the two groups before and after treatment ( P >0.05). The vaginal surface cells of the two groups were increased after treatment (P <0.05 or 0.01). After treatment, the vaginal surface cells of the observation group were better than the control group (P<0.05). The total effective rate was 88.14% in the observation group and 72.88% in the control group. The difference was statistically significant (P <0.05). Conclusion: The combination of nilestriol and metronidazole suppository in the treatment of patients with atrophic vaginitis is reliable, can effectively improve vaginal cleanliness, increase intravaginal epithelial cells, reduce vaginal pH, and can be used in clinical applications.