槟榔致癌性和毒性的药理学研究进展

Advances of pharmacological research on carcinogenicity and toxicity of areca nut

文章梳理归纳了多年来国内外有关槟榔致癌性和毒性的相关研究进展,从致癌组分、致癌性和毒性,以及其与口腔癌和肝癌等恶性癌症的发病具有密切的关系,全面阐述了槟榔诱发癌症尤其是口腔癌的作用机制,剖析其作为嗜好品嚼食兼具的生殖毒性、神经毒性等潜在的安全问题,指出加工过程的添加剂对癌变的影响也应引起注意。

This review examines the research progresses on carcinogenicity and toxicity of areca nut in recent years. After summarizing the carcinogenic components, carcinogenicity and toxicity, and the relationship with the incidence of malignant cancers, the review focus on the mechanism of areca inducing cancer, especially oral cancer, and its reproductive toxicity and neurotoxicity. Finally, the review concentrates on providing references for the prevention and treatment of oral submucosal fibrosis, oral cancer and other malignant diseases.