VEGF、Hsp70、IL-1β表达与自发性脑出血患者预后的相关性研究

Study on the Correlation between the Expression of Vascular Endothelial Growth Factor,Hsp70 and IL-1βand the Prognosis of Patients with Spontaneous Cerebral Hemorrhage

【目的】探讨自发性脑出血(SICH)患者血管内皮生长因子(VEGF)、热休克蛋白70(Hsp70)、白细胞介素-1g(L-β)水平与预后的相关性。【方法】选择2016年8月至2018年8月本院收治的96例确诊为SICH并接受手术治疗患者的临床资料,根据患者预后情况将其分为预后不良组(n=32)和预后良好组(n=64)。采用ELISA法检测血清VEGF、Hsp70和IL-1β水平,对患者进行GCS评分并测定血肿量,采用ROC曲线分析各指标对SICH预后预测价值。【结果】SICH预后不良组VEGF、Hsp70、IL-1β水平均显著高于预后良好组,差异均具有统计学意义(P<0.05)。经pearson相关分析,入院时血肿量与VEGF、Hsp70、IL-1β表达水平均呈正相关(P<0.05);入院时GCS评分与VEGF、Hsp70、IL-1β表达水平均呈负相关(P<0.05)。VEGF、Hsp70、IL-1β水平对SICH预后不良均有预测价值,具有统计学意义(P<0.05);入院GCS评分对SICH预后不良诊断价值最高,AUC为(0.768±0.047);VEGF水平与GCS评分的AUC比较,差异有统计学意义(P<0.05),血浆Hsp70、IL-1β水平与GCS评分的AUC比较,差异无统计学意义(P>0.05)。【结论】血清VEGF、Hsp70、IL-1β水平有助于反映SICH患者病情的严重程度,对预后不良预测有较高的临床应用价值。

【Objective】To explore the correlation between the levels of vascular endothelial growth factor(VEGF),heat shock protein 70(Hsp 70),interleukin-1(IL-1β)and prognosis in patients with spontaneous intracerebral hemorrhage(SICH).【Methods】From August 2016 to August 2018,96 patients with SICH diagnosed and treated by surgery were divided into poor prognosis group(n=32)and good prognosis group(n=64)according to their prognosis.Serum levels of vascular endothelial growth factor,Hsp 70 and IL-1βwere detected by ELISA.GCS scores and hematoma volume were measured.ROC curve was used to analyze the predictive value of each index for SICH prognosis.【Results】The levels of vascular endothelial growth factor,Hsp70 and IL-1βbeta in SICH patients with poor prognosis were significantly higher than those in patients with good prognosis(P<0.05).Pearson correlation analysis showed that the amount of hematoma at admission was positively correlated with the expression levels of VEGF,Hsp70 and IL-1β(P<0.05),while the GCS score at admission was negatively correlated with the expression levels of VEGF,Hsp70 and IL-lβbeta(P<0.05).The levels of VEGF,Hsp70 and IL-1βhad predictive value for the poor prognosis of SICH,with statistical significance(P<0.05);the GCS score at admission had the highest diagnostic value for the poor prognosis of SICH,with AUC(0.768士0.047);there was significant difference between the levels of VEGF and the AUC score of GCS(P<0.05);there was no significant difference between the levels of plasma Hsp70 and IL-1βand the AUC score of GCS(P>0.05).)【Conclusion】Serum levels of vascular endothelial growth factor(VEGF),Hsp70 and interleukin-1 are helpful to reflect the severity of SICH patients and have high clinical value in predicting poor prognosis.